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Recent advances in the genetics of distal hereditary motor neuropathy give insight to a disease mechanism involving copper homeostasis that may extend to other motor neuron disorders

Authors

  • ND Merner,

    1. Centre of Excellence in Neuromics of Université de Montréal, CHUM Research Center, Montreal, Quebec, Canada H2L 2W5
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  • PA Dion,

    1. Centre of Excellence in Neuromics of Université de Montréal, CHUM Research Center, Montreal, Quebec, Canada H2L 2W5
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  • GA Rouleau

    Corresponding author
    1. Centre of Excellence in Neuromics of Université de Montréal, CHUM Research Center, Montreal, Quebec, Canada H2L 2W5
      Guy A. Rouleau, CHUM Research Centre, 2099 Alexandre-de-Seve, Room Y-3633, Montreal, Quebec, Canada H2L 2W5.
      Tel.: +1-514-890-8000x24699;
      fax: +1-514-412-7602;
      e-mail: guy.rouleau@umontreal.ca
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Guy A. Rouleau, CHUM Research Centre, 2099 Alexandre-de-Seve, Room Y-3633, Montreal, Quebec, Canada H2L 2W5.
Tel.: +1-514-890-8000x24699;
fax: +1-514-412-7602;
e-mail: guy.rouleau@umontreal.ca

Abstract

Merner ND, Dion PA, Rouleau GA. Recent advances in the genetics of distal hereditary motor neuropathy give insight to a disease mechanism involving copper homeostasis that may extend to other motor neuron disorders.

Distal hereditary motor neuropathy (dHMN) is a sub-group of Charcot–Marie–Tooth disease (CMT), the most common peripheral neuropathy, that affects only motor neurons. The recent observation of ATP7A mutations in dHMN provides insight for a common disease mechanism that may involve copper homeostasis. Functionally, diverse proteins were previously shown to underlie dHMN and a convergent link is destined to unfold for some of these. We propose connections between copper and known dHMN genes that overlap also with the causative genes of other motor neuron disorders (MNDs).

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