Spanish MYH7 founder mutation of Italian ancestry causing a large cluster of Laing myopathy patients
Article first published online: 11 APR 2011
© 2011 John Wiley & Sons A/S
Volume 81, Issue 5, pages 491–494, May 2012
How to Cite
Muelas, N., Hackman, P., Luque, H., Suominen, T., Espinós, C., Garcés-Sánchez, M., Sevilla, T., Azorín, I., Millán, J., Udd, B. and Vílchez, J. (2012), Spanish MYH7 founder mutation of Italian ancestry causing a large cluster of Laing myopathy patients. Clinical Genetics, 81: 491–494. doi: 10.1111/j.1399-0004.2011.01667.x
- Issue published online: 11 APR 2012
- Article first published online: 11 APR 2011
- Accepted manuscript online: 11 MAR 2011 02:50PM EST
- Received 3 February 2011, revised and accepted for publication 9 March 2011
- founder mutation;
- Laing myopathy;
- p.K1729del mutation
Muelas N, Hackman P, Luque H, Suominen T, Espinós C, Garcés-Sánchez M, Sevilla T, Azorín I, Millán JM, Udd B, Vílchez JJ. Spanish MYH7 founder mutation of Italian ancestry causing a large cluster of Laing myopathy patients.
Laing myopathy is a distal myopathy caused by mutations in the tail of the slow beta-myosin heavy chain gene MYH7. A large cluster of patients belonging to different families, with Laing myopathy due to p.K1729del mutation, was found in the Safor region, Spain. The same mutation was previously reported in an American family with Italian ancestry. The possibility that p.K1729del in MYH7 might be a founder mutation in the Safor patients and the chance of a common origin with the Italian-American family mutation was investigated by haplotype analyses, mutation data origin estimation and historical inquiry. Our results show that the p.K1729del in MYH7 harboured by patients from the Safor indeed is a founder mutation. A common ancestral origin of this mutation in the Spanish and Italian families is also suggested because they all share a core SNP haplotype at locus MYH7. Data estimation yields the origin of the mutation in the Safor at the beginning of the XVII century, when the Moorish were spelt and the region was resettled with Italian families.