High frequency of autosomal-recessive DFNB59 hearing loss in an isolated Arab population in Israel
Article first published online: 18 JUL 2011
© 2011 John Wiley & Sons A/S
Volume 82, Issue 3, pages 271–276, September 2012
How to Cite
Borck, G., Rainshtein, L., Hellman-Aharony, S., Volk, A., Friedrich, K., Taub, E., Magal, N., Kanaan, M., Kubisch, C., Shohat, M. and Basel-Vanagaite, L. (2012), High frequency of autosomal-recessive DFNB59 hearing loss in an isolated Arab population in Israel. Clinical Genetics, 82: 271–276. doi: 10.1111/j.1399-0004.2011.01741.x
- Issue published online: 12 AUG 2012
- Article first published online: 18 JUL 2011
- Accepted manuscript online: 23 JUN 2011 04:50AM EST
- Received 13 May 2011, revised and accepted for publication 20 June 2011
- hearing loss
Borck G, Rainshtein L, Hellman-Aharony S, Volk AE, Friedrich K, Taub E, Magal N, Kanaan M, Kubisch C, Shohat M, Basel-Vanagaite L. High frequency of autosomal-recessive DFNB59 hearing loss in an isolated Arab population in Israel.
Autosomal-recessive non-syndromic hearing impairment (DFNB) is usually of prelingual onset with a moderate to profound degree of hearing loss. More than 70 DFNB loci have been mapped and ∼40 causative genes have been identified. Non-syndromic hearing impairment caused by mutations of DFNB59 (encoding pejvakin) has been described in a couple of families in which affected individuals presented with either auditory neuropathy or hearing loss of cochlear origin. We have identified and clinically evaluated three consanguineous families of Israeli Arab origin with prelingual non-syndromic hearing impairment and absent otoacoustic emissions in a total of eight affected individuals. All the families originate from the same village and bear the same family name. We have identified a c.406C>T (p.R136X) nonsense mutation in the DFNB59 gene in affected individuals from these families. Among the inhabitants of the village, we found an exceptionally high carrier frequency of ∼1 in 12 individuals (7/85; 8.2%). The high prevalence of hearing impairment can be explained by a founder effect and the high consanguinity rate among the inhabitants of this village.