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Polycystin-1: a key player in hereditary cystic kidney and liver disorders


  • NH Skotte

    Corresponding author
    1. Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada
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1.Drenth JP, Martina JA, van de Kerkhof R, Bonifacino JS, Jansen JB. Polycystic liver disease is a disorder of cotranslational protein processing. Trends Mol Med 2005: 11: 3742.

2.Vembar SS, Brodsky JL. One step at a time: endoplasmic reticulum-associated degradation. Nat Rev Mol Cell Biol 2008: 9: 944957.

3.Harris PC, Torres VE. Polycystic kidney disease. Annu. Rev. Med 2009: 60: 321337.

A genetic interaction network of five genes for human polycystic kidney and liver diseases defines polycystin-1 as the central determinant of cyst formation.

Fedeles et al. (2011)

Nature Genetics 43(7):639–647.

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