Nothing to declare.
Opioid genetics: the key to personalized pain control?
Article first published online: 26 JUL 2012
© 2012 John Wiley & Sons A/S
Volume 82, Issue 4, pages 301–310, October 2012
How to Cite
Opioid genetics: the key to personalized pain control?, , .
- Issue published online: 11 SEP 2012
- Article first published online: 26 JUL 2012
- Accepted manuscript online: 10 JUL 2012 07:12AM EST
- Manuscript Accepted: 29 JUN 2012
- Manuscript Revised: 25 JUN 2012
- Manuscript Received: 4 JUN 2012
There are now several strong opioids available to choose from for the relief of moderate to severe pain. On a population level, there is no difference in terms of analgesic efficacy or adverse reactions between these drugs; however, on an individual level there is marked variation in response to a given opioid. The genetic influences to this variation are complex, and although current research has shown some promising results, these have not been replicated across larger studies and as such the ultimate aim of personalized prescribing remains elusive. If personalized prescribing could be achieved this would have a major impact at an individual level to facilitate safe, effective and rapid symptom control. This review presents some of the recent positive advances in opioid pharmacogenetic studies, focusing on associations between candidate genes and the three main elements of opioid response: analgesic, upper gastrointestinal and central adverse reactions.