Nothing to declare.
From mouse to humans: discovery of the CACNG2 pain susceptibility gene
Article first published online: 26 JUL 2012
© 2012 John Wiley & Sons A/S
Volume 82, Issue 4, pages 311–320, October 2012
How to Cite
From mouse to humans: discovery of the CACNG2 pain susceptibility gene..
- Issue published online: 11 SEP 2012
- Article first published online: 26 JUL 2012
- Accepted manuscript online: 6 JUL 2012 01:25PM EST
- Manuscript Revised: 29 JUN 2012
- Manuscript Accepted: 29 JUN 2012
- Manuscript Received: 31 MAY 2012
- animal model;
- complex trait;
- integrated approach;
- neuropathic pain;
- pain genes
Chronic pain is a major healthcare problem affecting the daily lives of millions with enormous financial costs. The notorious variability and lack of efficient pain relief pharmaceuticals provide both genetic and therapeutic challenge. There are several genetic approaches that aim to uncover the molecular nature of pain phenotypes into their genetic components. Gene mapping using model organisms for various pain phenotypes has led to the identification of novel genes affecting susceptibility and response to pain stimuli. Translational studies have succeeded to tie those genes to human pain syndromes, thus suggesting new targets for drug discovery. In this short review, a perspective on pain genetics and the trajectory from pain phenotype to pain gene involving fine-mapping strategies, bioinformatic analysis and microarray profiling alongside human association analysis will be introduced. This integrated approach has led to identification of CACNG2 as a novel neuropathic pain gene affecting pain susceptibility both in mice and humans. It also serves as a prototype for efficient and economic discovery of pain genes. Comparisons to other methods as well as future directions of pain genetics will be discussed as well.