Chair, Division of Nephrology.
Steroid withdrawal five days after renal transplantation allows for the prevention of wound-healing complications associated with sirolimus therapy
Article first published online: 24 AUG 2008
© 2009 John Wiley & Sons A/S
Volume 23, Issue 1, pages 16–22, January/February 2009
How to Cite
Sandrini, S., Setti, G., Bossini, N., Maffei, C., Iovinella, L., Tognazzi, N., Maffeis, R., Nodari, F., Portolani, N. and Cancarini, G. (2009), Steroid withdrawal five days after renal transplantation allows for the prevention of wound-healing complications associated with sirolimus therapy. Clinical Transplantation, 23: 16–22. doi: 10.1111/j.1399-0012.2008.00890.x
All the authors declare that they have received no support from any company and that there is no relationship with any company.
- Issue published online: 19 JAN 2009
- Article first published online: 24 AUG 2008
- Accepted for publication 5 July 2008
- kidney transplantation;
- steroid withdrawal;
- wound complication
Abstract: Background: Sirolimus (SRL) can increase the risk of wound complications. In this study, we investigated the impact of steroids when added to SRL, in this side effect.
Methods: One hundred and forty-eight patients entered prospective studies comparing early (fifth day) with late (sixth month) steroid withdrawal. All patients were on SRL, added either to Tacrolimus (n = 56) or to cyclosporine (n = 97). At 15th day after transplantation, 68 patients were on steroids (On-St group) and 80 were not (Off-St group). Wound complications considered were as follows: dehiscence, lymphocele, wound leakage, hematoma and seromas. Risk factors under analysis were as follows: body mass index, diabetes, rejection, creatininemia, length of dialysis before transplantation, recipient age, being on steroids at 15th day, SRL levels.
Results: The overall incidence of wound complications was significantly lower in Off-St group than in On-St group: 18.8% vs. 45.6%, respectively (p < 0.0004). In detail, lymphocele: 5.0% vs. 32.3% (p < 0.0001); dehiscence 0% vs. 10.3% (p < 0.009), leakage 6.2% vs. 8.8% (p = NS), seromas 1.4% vs. 7.5% (NS). At multivariate analysis, the addition of steroids to SRL increases 4.2-fold the risk for wound complications.
Conclusions: Early steroid withdrawal is effective in preventing both the incidence and the severity of wound-healing complications because of SRL regime, even when started with a loading dose.