Conflict of interest: None.
Taking immunosuppressive medications effectively (TIMELink): a pilot randomized controlled trial in adult kidney transplant recipients
Article first published online: 16 NOV 2010
© 2010 John Wiley & Sons A/S
Volume 25, Issue 6, pages 864–870, November/December 2011
How to Cite
Russell, C., Conn, V., Ashbaugh, C., Madsen, R., Wakefield, M., Webb, A., Coffey, D. and Peace, L. (2011), Taking immunosuppressive medications effectively (TIMELink): a pilot randomized controlled trial in adult kidney transplant recipients. Clinical Transplantation, 25: 864–870. doi: 10.1111/j.1399-0012.2010.01358.x
- Issue published online: 9 DEC 2011
- Article first published online: 16 NOV 2010
- Accepted for publication 30 September 2010
- electronic monitoring;
- medication adherence;
- randomized controlled trial;
Russell C, Conn V, Ashbaugh C, Madsen R, Wakefield M, Webb A, Coffey D, Peace L. Taking immunosuppressive medications effectively (TIMELink): a pilot randomized controlled trial in adult kidney transplant recipients. Clin Transplant 2011: 25: 864–870. © 2010 John Wiley & Sons A/S.
Abstract: Background: Immunosuppressive medication non-adherence is one of the most prevalent but preventable causes of poor outcomes in adult renal transplant recipients, yet there is a paucity of studies testing interventions in this area.
Methods: Using a randomized controlled trial design, 30 adult renal transplant recipients were screened for medication non-adherence using electronic monitoring. Fifteen non-adherent participants were randomized to receive either a continuous self-improvement intervention or attention control management. The six-month continuous self-improvement intervention involved the participant and clinical nurse specialist collaboratively identifying the person’s life routines, important people, and possible solutions to enhance medication taking. The participant then received individual monthly medication taking feedback delivered via a graphic printout of daily medication taking generated from electronic monitoring.
Results: The mean medication adherence score for the continuous self-improvement intervention group (n = 8) was statistically significantly higher than the attention control group’s (n = 5) mean medication adherence score (p = 0.03). The continuous self-improvement intervention effect size (Cohen’s d) was large at 1.4. Participants’ perceptions of the intervention were highly favorable.
Conclusions: The continuous self-improvement intervention shows promise as an effective and feasible approach to improve medication adherence in adult renal transplant recipients. A fully-powered study with a diverse sample is needed to confirm these preliminary findings.