Clinical study on prevention of HBV re-infection by entecavir after liver transplantation

Authors

  • Chang-jie Cai,

    1. Liver Transplant Center, The Third Affiliated Hospital of Sun Yat-sen University, Transplantation Research Institute of Sun Yat-sen University, Guangzhou, China
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  • Min-qiang Lu,

    1. Liver Transplant Center, The Third Affiliated Hospital of Sun Yat-sen University, Transplantation Research Institute of Sun Yat-sen University, Guangzhou, China
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  • Ying-hua Chen,

    1. Liver Transplant Center, The Third Affiliated Hospital of Sun Yat-sen University, Transplantation Research Institute of Sun Yat-sen University, Guangzhou, China
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  • Hui Zhao,

    1. Liver Transplant Center, The Third Affiliated Hospital of Sun Yat-sen University, Transplantation Research Institute of Sun Yat-sen University, Guangzhou, China
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  • Min-ru Li,

    1. Liver Transplant Center, The Third Affiliated Hospital of Sun Yat-sen University, Transplantation Research Institute of Sun Yat-sen University, Guangzhou, China
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  • Gui-hua Chen

    1. Liver Transplant Center, The Third Affiliated Hospital of Sun Yat-sen University, Transplantation Research Institute of Sun Yat-sen University, Guangzhou, China
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  • Conflict of interest: None.

  • Chang-jie Cai and Min-qiang Lu contributed equally to this work.

Corresponding author: Min-qiang Lu, MD, PhD, Liver Transplant Center, the Third Affiliated Hospital of Sun Yat-sen University, Transplantation Research Institute of Sun Yat-sen University, Guangzhou 510630, China.
Tel.: 0086 020 85252396; fax: 0086 020 85252396;
e-mail: lmq_gzb@21cn.net

Abstract

Cai C-j, Lu M-q, Chen Y-h, Zhao H, Li M-r, Chen G-h. Clinical study on prevention of HBV re-infection by entecavir after liver transplantation.
Clin Transplant 2011 DOI: 10.1111/j.1399-0012.2011.01448.x.
© 2011 John Wiley & Sons A/S.

Abstract:  Purpose:  This aims to evaluate the effects of lamivudine (LAM) and entecavir (ETV) in preventing hepatitis B virus (HBV) re-infection after liver transplantation (LT).

Methods:  A retrospective matched case-control method was used in this study. From June 2005 to May 2007, the patients who received LAM (100 mg qd) or ETV (0.5 mg qd) were chosen. The LAM and ETV groups were matched using a 3:1 ratio based on the factors, such as age, gender, LAM or ETV antiviral duration, primary disease, and HBV DNA levels at the initiation of antiviral therapy. Data on serum HBV markers, HBV DNA, and cumulative recurrence were collected.

Results:  Two hundred and fifty-two patients were enrolled. The average duration of follow-up was 38.5 and 41.2 months (LAM and ETV groups) (p > 0.05). Duration of pre-operative antiviral therapy was 30.3 and 25.8 d (LAM and ETV groups) (p > 0.05). The HBV DNA level decreased from 3.89 × 106 to 5.31 × 105 copies/mL before LT in the LAM group, and decreased from 8.74 × 106 to 5.49 × 104 copies/mL in the ETV group (p < 0.05). Eighteen patients in LAM group developed HBV re-infection and 0 in ETV group.

Conclusion:  ETV is superior to LAM for preventing HBV re-infection following LT.

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