Conflict of interest: None.
Prevalence and risk factors of polyomavirus BK replication in simultaneous pancreas/kidney transplant recipients from a single transplant center
Article first published online: 21 AUG 2011
© 2011 John Wiley & Sons A/S
Volume 26, Issue 2, pages 267–274, March/April 2012
How to Cite
Mindlova, M., Boucek, P., Saudek, F., Skibova, J., Jedinakova, T., Lipar, K., Adamec, M. and Hirsch, H. H. (2012), Prevalence and risk factors of polyomavirus BK replication in simultaneous pancreas/kidney transplant recipients from a single transplant center. Clinical Transplantation, 26: 267–274. doi: 10.1111/j.1399-0012.2011.01488.x
- Issue published online: 16 APR 2012
- Article first published online: 21 AUG 2011
- Accepted for publication 05 April 2011
- risk factors;
Mindlova M, Boucek P, Saudek F, Skibova J, Jedinakova T, Lipar K, Adamec M, Hirsch HH. Prevalence and risk factors of polyomavirus BK replication in simultaneous pancreas/kidney transplant recipients from a single transplant center. Clin Transplant 2011 DOI: 10.1111/j.1399-0012.2011.01488.x. © 2011 John Wiley & Sons A/S.
Abstract: Background: BK virus (BKV) replication is considered as a marker of risk for polyomavirus BK-associated nephropathy (PVAN). We evaluated the occurrence and risk factors for BKV DNA positivity following simultaneous pancreas/kidney transplantation (SPK).
Methods: Point prevalence of BK viruria and viremia was assessed in 183 SPK recipients. Real-time polymerase chain reaction was used with a detection threshold of 103 copies/mL. High-level BKV positivity was defined as viruria and/or viremia >107 and >104 copies/mL, respectively. BKV-positive patients were retested after 4–13 months and underwent an additional six-month clinical follow-up.
Results: Urine and serum BKV positivity was detected in 28 (17.3% of available samples) and 7 (3.8%) patients, with high-level viruria and viremia occurring in 6 (3.7%) and 3 (1.6%) patients, respectively. PVAN was biopsy-confirmed in 1 and suspected as a cause of progressive renal failure in another SPK recipient. Patients with single low-level viruria did not progress to high-level positivity or PVAN at follow-up. In multivariate analysis, pre-transplant diabetes duration and delayed graft function were independently associated with BKV positivity.
Conclusions: Point prevalence of high-level BKV positivity and PVAN was low in SPK recipients from a single center. Diabetes duration and delayed graft function were independent risk factors for BKV replication.