Conflict of interest: None.
Self-reported non-adherence to immune-suppressant therapy in liver transplant recipients: demographic, interpersonal, and intrapersonal factors
Article first published online: 29 SEP 2011
© 2011 John Wiley & Sons A/S.
Volume 26, Issue 2, pages 328–335, March/April 2012
How to Cite
Lamba, S., Nagurka, R., Desai, K. K., Chun, S. J., Holland, B. and Koneru, B. (2012), Self-reported non-adherence to immune-suppressant therapy in liver transplant recipients: demographic, interpersonal, and intrapersonal factors. Clinical Transplantation, 26: 328–335. doi: 10.1111/j.1399-0012.2011.01489.x
- Issue published online: 16 APR 2012
- Article first published online: 29 SEP 2011
- Accepted for publication 20 May 2011
- immune suppression;
- liver transplantation
Lamba S, Nagurka R, Desai KK, Chun SJ, Holland B, Koneru B. Self-reported non-adherence to immune-suppressant therapy in liver transplant recipients: demographic, interpersonal, and intrapersonal factors. Clin Transplant 2011 DOI: 10.1111/j.1399-0012.2011.01489.x. © 2011 John Wiley & Sons A/S.
Abstract: Adherence to immune suppressants and follow-up care regimen is important in achieving optimal long-term outcomes after organ transplantation. To identify patients most at risk for non-adherence, this cross-sectional, descriptive study explores the prevalence and correlates of non-adherence to immune-suppressant therapy among liver recipients. Anonymous questionnaires mailed consisted of the domains: (i) adherence barriers to immune suppressants, (ii) immune suppressants knowledge, (iii) demographics, (iv) social support, (v) medical co-morbidities, and (vi) healthcare locus of control and other beliefs. Overall response was 49% (281/572). Data analyzed for those transplanted within 10 yr of study reveal 50% (119/237) recipients or 9.2/100 person years reporting non-adherence. Non-adherence was reported highest in the 2–5 yr post-transplant phase (69/123, 56%). The highest immune-suppressant non-adherence rates were in recipients who are: divorced (26/34, 76%, p = 0.0093), have a history of substance or alcohol use (42/69, 61%, p = 0.0354), have mental health needs (50/84, 60%, p = 0.0336), those who missed clinic appointments (25/30, 83%, p < 0.0001), and did not maintain medication logs (71/122, 58%, p = 0.0168). Respondents who were non-adherent with physician appointments were more than four and a half times as likely (OR 4.7, 95% CI 1.5–14.7, p = 0.008) to be non-adherent with immune suppressants. In conclusion, half of our respondents report non-adherence to immune suppressants. Factors identified may assist clinicians to gauge patients’ non-adherence risk and target resources.