Conflict of interest: There are no conflicts of interest between the authors of this article.
Is adiponectin a marker of preclinical atherosclerosis in kidney transplantation?
Version of Record online: 12 DEC 2011
© 2011 John Wiley & Sons A/S
Volume 26, Issue 2, pages 259–266, March/April 2012
How to Cite
Cañas, L., Bayés, B., Granada, M. L., Ibernon, M., Porrini, E., Benítez, R., Díaz, J. M., Lauzurica, R., Moreso, F., Torres, A., Lampreabe, I., Serra, A. and Romero, R. (2012), Is adiponectin a marker of preclinical atherosclerosis in kidney transplantation?. Clinical Transplantation, 26: 259–266. doi: 10.1111/j.1399-0012.2011.01490.x
- Issue online: 16 APR 2012
- Version of Record online: 12 DEC 2011
- Accepted for publication 7 April 2011
- altered glucose homeostasis;
- carotid intima-media thickness;
- carotid ultrasound;
- kidney transplantation
Cañas L, Bayés B, Granada ML, Ibernon M, Porrini E, Benítez R, Díaz JM, Lauzurica R, Moreso F, Torres A, Lampreabe I, Serra A, Romero R. Is adiponectin a marker of preclinical atherosclerosis in kidney transplantation? Clin Transplant 2011 DOI: 10.1111/j.1399-0012.2011.01490.x. © 2011 John Wiley & Sons A/S.
Abstract: The aim of this study was to analyze the relationship between pre-transplant adiponectin (pre-ADP), abnormalities in glucose homeostasis (AGH) at three months post-transplantation, and preclinical atherosclerosis in non-diabetic patients prior to kidney transplantation (KT).
Methods: We carried out a multicenter study in 157 non-diabetic KT patients (66.5% men; age: 50 ± 13 yr). Pre-ADP levels were analyzed using radioimmunoassay. Carotid ultrasound was performed to determine carotid intima-media thickness (c-IMT). Oral glucose tolerance test was carried out to classify patients according ADA criteria.
Results: Of the patients, 52.8% had AGH. Median pre-ADP was 19.5 (14–27) μg/mL. An inverse correlation was found between ADP and HOMA index (r = −0.432; p < 0.001). Median c-IMT was 0.6 (0.48–0.71) mm. Significant inverse correlation existed between ADP and c-IMT on both sides (p < 0.05). Patients with c-IMT >0.6 mm had more AGH (p = 0.012) and lower ADP levels (p = 0.02). We performed a logistic regression analysis using preclinical atherosclerosis (c-IMT ≥0.6 mm) as dependent variable and sex, age, BMI, ADP, AGH, and HOMA index as independent variables of altered c-IMT. Age, pre-ADP, and AGH were independent risk factors for elevated c-IMT.
Conclusions: Patients with AGH have a greater presence of preclinical atherosclerosis. ADP has an inverse relationship with AGH and is an independent marker of preclinical atherosclerosis.