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Keywords:

  • adiponectin;
  • altered glucose homeostasis;
  • carotid intima-media thickness;
  • carotid ultrasound;
  • kidney transplantation

Cañas L, Bayés B, Granada ML, Ibernon M, Porrini E, Benítez R, Díaz JM, Lauzurica R, Moreso F, Torres A, Lampreabe I, Serra A, Romero R. Is adiponectin a marker of preclinical atherosclerosis in kidney transplantation? Clin Transplant 2011 DOI: 10.1111/j.1399-0012.2011.01490.x. © 2011 John Wiley & Sons A/S.

Abstract:  The aim of this study was to analyze the relationship between pre-transplant adiponectin (pre-ADP), abnormalities in glucose homeostasis (AGH) at three months post-transplantation, and preclinical atherosclerosis in non-diabetic patients prior to kidney transplantation (KT).

Methods:  We carried out a multicenter study in 157 non-diabetic KT patients (66.5% men; age: 50 ± 13 yr). Pre-ADP levels were analyzed using radioimmunoassay. Carotid ultrasound was performed to determine carotid intima-media thickness (c-IMT). Oral glucose tolerance test was carried out to classify patients according ADA criteria.

Results:  Of the patients, 52.8% had AGH. Median pre-ADP was 19.5 (14–27) μg/mL. An inverse correlation was found between ADP and HOMA index (r = −0.432; p < 0.001). Median c-IMT was 0.6 (0.48–0.71) mm. Significant inverse correlation existed between ADP and c-IMT on both sides (p < 0.05). Patients with c-IMT >0.6 mm had more AGH (p = 0.012) and lower ADP levels (p = 0.02). We performed a logistic regression analysis using preclinical atherosclerosis (c-IMT ≥0.6 mm) as dependent variable and sex, age, BMI, ADP, AGH, and HOMA index as independent variables of altered c-IMT. Age, pre-ADP, and AGH were independent risk factors for elevated c-IMT.

Conclusions:  Patients with AGH have a greater presence of preclinical atherosclerosis. ADP has an inverse relationship with AGH and is an independent marker of preclinical atherosclerosis.