Inverse association of serum long-acting natriuretic peptide and bone mineral density in renal transplant recipients

Authors


  • Conflict of interest: None.

Corresponding author: Ming-Che Lee, Department of Surgery, Buddhist Tzu Chi General Hospital, No. 707, Section 3, Chung-Yang Road, Hualien, Taiwan.
Tel.: +886 3 8561825; fax: +886 3 8577161; e-mail: mclee@tzuchi.com.tw

Abstract

Hsu B-G, Ho G-J, Lee C-J, Yang Y-C, Chen Y-C, Shih M-H, Lee M-C. Inverse association of serum long-acting natriuretic peptide and bone mineral density in renal transplant recipients.
Clin Transplant 2011 DOI: 10.1111/j.1399-0012.2011.01575.x.
© 2011 John Wiley & Sons A/S.

Abstract:  Objective:  Our aim was to evaluate the relationship between bone mineral density (BMD) and fasting serum long-acting natriuretic peptide (LANP) concentration in renal transplant recipients.

Patients and methods:  Fasting blood samples were obtained from 65 renal transplant recipients. BMD was measured using dual energy X-ray absorptiometry in lumbar vertebrae (L2–L4). Serum LANP levels were measured using a commercial enzyme immunoassay kit.

Results:  Six patients (9.2%) had osteoporosis and 28 patients (43.1%) had osteopenia in renal transplant recipients. Increased serum LANP (p < 0.001) was significantly correlated with low lumbar T-score cut-off points between groups (normal, osteopenia, and osteoporosis) in renal transplant recipients. Female patients had lower lumbar BMD than male renal transplant recipients (p = 0.027). Univariate linear regression analysis indicated that lumbar BMD were positively correlated with height (p = 0.038), body weight (p = 0.003), and body mass index (BMI; p = 0.019), whereas negatively correlated with LANP (p = 0.004) among the renal transplant recipients. Multivariate forward stepwise linear regression analysis of the significant variables revealed that body weight (R2 change = 0.132; p = 0.006) and LANP (R2 change = 0.093; p = 0.008) were the independent predictors of lumbar BMD values in the renal transplant recipients.

Conclusion:  Serum LANP concentration correlates negatively with lumbar BMD values in renal transplant recipients.

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