Living donor kidney paired donation transplantation: experience as a founding member center of the National Kidney Registry
Article first published online: 12 MAR 2012
© 2012 John Wiley & Sons A/S
Volume 26, Issue 3, pages E213–E222, May/June 2012
How to Cite
Leeser DB, Aull MJ, Afaneh C, Dadhania D, Charlton M, Walker JK, Hartono C, Serur D, Del Pizzo JJ, Kapur S. Living donor kidney paired donation transplantation: experience as a member center of the National Kidney Registry. Clin Transplant 2012 DOI: 10.1111/j.1399-0012.2012.01606.x. © 2012 John Wiley & Sons A/S.
- Issue published online: 12 JUN 2012
- Article first published online: 12 MAR 2012
- Manuscript Accepted: 29 DEC 2011
- kidney paired donation;
- kidney transplantation;
- living donation;
Kidney paired donation (KPD) is a safe and effective means of transplantation for transplant candidates with willing but incompatible donors. We report our single-center experience with KPD through participation in the National Kidney Registry. Patient demographics, transplant rates, and clinical outcomes including delayed graft function (DGF), rejection, and survival were analyzed. We also review strategies employed by our center to maximize living donor transplantation through KPD. We entered 44 incompatible donor/recipient pairs into KPD from 9/2007 to 1/2011, enabling 50 transplants. Incompatibility was attributable to blood type (54.4%) and donor-specific sensitization (43.2%). Thirty-six candidates (81.8%) were transplanted after 157 d (median), enabling pre-emptive transplantation in eight patients. Fourteen candidates on the deceased donor waiting list also received transplants. More than 50% of kidneys were received from other transplant centers. DGF occurred in 6%; one-yr rejection rate was 9.1%. One-yr patient and graft survival was 98.0% and 94.8%. KPD involving participation of multiple transplant centers can provide opportunities for transplantation, with potential to expand the donor pool, minimize waiting times, and enable pre-emptive transplantation. Our experience demonstrates promising short-term outcomes; however, longer follow-up is needed to assess the impact of KPD on the shortage of organs available for transplantation.