Conflict of interest: All the authors declare no competing financial interests.
High frequency of CD4+CD25−CD69+T cells is correlated with a low risk of acute graft-versus-host disease in allotransplants
Article first published online: 16 APR 2012
© 2012 John Wiley & Sons A/S
Volume 26, Issue 2, pages E158–E167, March/April 2012
How to Cite
Lu S-Y, Huang X-J, Liu K-Y, Liu D-H, Xu L-P. High frequency of CD4+CD25−CD69+ T cells is correlated with a low risk of acute graft-versus-host disease in allotransplants.
- Issue published online: 16 APR 2012
- Article first published online: 16 APR 2012
- Manuscript Accepted: 6 FEB 2012
- National Outstanding Young Scientist's Foundation of China. Grant Number: 30725038
- National Natural Science Foundation of China. Grant Numbers: 30971292, 30800485
- Innovative Research Team. Grant Number: IRT0702
- acute graft-versus-host disease;
- allogeneic hematopoietic cell transplantation;
- regulatory T cells
Regulatory T cells (Tregs) maintain transplantation tolerance and suppress graft-versus-host disease (GvHD) in humans. We monitored 17 subjects with acute GvHD to determine whether Treg frequency correlates with acute GvHD. We found the percent of CD4+CD25−CD69+ Tregs decreases when acute GvHD develops and increases after acute GvHD is controlled. We next sequentially studied 50 subjects receiving conventional allotransplants. We show a high frequency and increased numbers of CD4+CD25−CD69+ Tregs are associated with a reduced risk of acute GvHD. We also show that CD4+CD25−CD69+ Treg numbers increase substantially early after allografts and that a low percent of CD4+CD25−CD69+Tregs is associated with an increased risk of acute GvHD. Reconstitution of Tregs early post-transplant is associated with less acute GvHD. These data imply that CD4+CD25−CD69+ Tregs are a novel subset of regulatory T cells that may protect against acute GvHD after allotransplants.