HLA Antibodies and Period of Gestation: Decline in Frequency of Positive Sera during Last Trimester


  • We thank M. Nabholz for advice and discussion.

Address: Jorge Vives Sección de Inmunología Hospital Clinico c/Casanova, 143 Barcelona 11 Spain


The incidence of cytotoxic antibodies in relation to the number of pregnancies and the different periods of gestation was analysed in sera from 2,686 pregnant women.

In all groups, except among women pregnant more than five times, a significant decline in the incidence of active sera occurred during the last trimester of gestation.