The Structure and Evolution of the HLA-Bw4 and Bw6 Antigens

Authors

  • Colin J. Barnstable,

    1. Genetics Laboratory, Department of Biochemistry, Oxford
    2. Department of Neurobiology, Harvard Medical School, Boston, Mass., U.S.A.
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  • David Snary,

    1. National Institute for Medical Research, Mill Hill, London, England
    2. Department of Immunochemistry, The Wellcome Research Laboratories, Langley Court, Beckenham, Kent, England
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  • Michael J. Crumpton,

    1. National Institute for Medical Research, Mill Hill, London, England
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  • Walter F. Bodmer

    Corresponding author
    1. Genetics Laboratory, Department of Biochemistry, Oxford
      Address: Prof. W. F. Bodmer Genetics Laboratory Dept. of Biochemistry South Parks Road Oxford, OX1 3QU England
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Address: Prof. W. F. Bodmer Genetics Laboratory Dept. of Biochemistry South Parks Road Oxford, OX1 3QU England

Abstract

The HLA-Bw4 and Bw6 antigenic determinants have been shown to co-migrate with HLA-B determinants on gel-filtration, sucrose density gradient centrifugation and affinity chromatography, using Lens culinaris lectin and antibody against human β2 microbulin. These and other published data imply that the HLA-Bw4 and Bw6 determinants reside on the same polypeptide chain as other HLA-B locus determinants. The implications of this in terms of the evolution of cross reacting groups of antigens at the HLA-B locus are discussed.

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