The Association of Goitrous Autoimmune Thyroiditis with HLA-DR5*

Authors

  • Nadir R. Farid,

    Corresponding author
    1. Thyroid Research Laboratory, Health Sciences Center, Memorial University of Newfoundland, St. John's, Newfoundland, Canada
      Address: Dr. Nadir R. Farid Thyroid Research Laboratory, Health Sciences Center, St. John's, Newfoundland, Canada, A1B 3V6
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  • Laura Sampson,

    1. Thyroid Research Laboratory, Health Sciences Center, Memorial University of Newfoundland, St. John's, Newfoundland, Canada
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  • Hilda Moens,

    1. Thyroid Research Laboratory, Health Sciences Center, Memorial University of Newfoundland, St. John's, Newfoundland, Canada
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  • John M. Barnard

    1. Thyroid Research Laboratory, Health Sciences Center, Memorial University of Newfoundland, St. John's, Newfoundland, Canada
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  • *

    Supported by grants from the M.R.C. Canada and the National Foundation - March of Dimes.

Address: Dr. Nadir R. Farid Thyroid Research Laboratory, Health Sciences Center, St. John's, Newfoundland, Canada, A1B 3V6

Abstract

We found HLA-DR5 to be present among 53% of 40 patients with goitrous autoimmune (Hashimoto's) thyroiditis compared to 26% of 80 controls. No deviations from those expected in the incidences of HLA-A, B, C antigens were seen. In contrast HLA-DR3 was increased among 50 patients with atrophic thyroiditis (65%) compared to controls (24%). These findings stress the immunogenetic heterogeneity between the goitrous and atrophic varieties of thyroiditis.

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