Abortion May Sensitize the Mother to HLA Antigens

Authors

  • A. Gelabert,

    Corresponding author
    1. Servicios de Hemoterapia, Hospital Clínico y Provincial, Barcelona, Spain
      Address: A . Gelabert, M. D. Servicio de Hemoterapia, Hospital Clinico y Provincial, c/ Casanova, 143, Barcelona-36, Spain
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  • J. Balasch,

    1. Servicios de Hemoterapia, Hospital Clínico y Provincial, Barcelona, Spain
    2. Obstetricia y Ginecología, Hospital Clínico y Provincial, Barcelona, Spain
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  • G. Ercilla,

    1. Servicios de Hemoterapia, Hospital Clínico y Provincial, Barcelona, Spain
    2. InmunologAía, Hospital Clínico y Provincial, Barcelona, Spain
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  • J. A. Vanrell,

    1. Servicios de Hemoterapia, Hospital Clínico y Provincial, Barcelona, Spain
    2. Obstetricia y Ginecología, Hospital Clínico y Provincial, Barcelona, Spain
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  • J. Vives,

    1. Servicios de Hemoterapia, Hospital Clínico y Provincial, Barcelona, Spain
    2. InmunologAía, Hospital Clínico y Provincial, Barcelona, Spain
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  • J. González-Merlo,

    1. Servicios de Hemoterapia, Hospital Clínico y Provincial, Barcelona, Spain
    2. Obstetricia y Ginecología, Hospital Clínico y Provincial, Barcelona, Spain
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  • R. Castillo

    1. Servicios de Hemoterapia, Hospital Clínico y Provincial, Barcelona, Spain
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Address: A . Gelabert, M. D. Servicio de Hemoterapia, Hospital Clinico y Provincial, c/ Casanova, 143, Barcelona-36, Spain

Abstract

The incidence of cytotoxic antibodies in relation to histories of abortions was analyzed in sera from 474 nulliparous pregnant women. In patients with previous spontaneous abortions, there is a higher incidence of positive sera than in primigravidae. Furthermore, patients with two or more prior abortions show a greater incidence of cytotoxic activity in their sera than women who have had only one abortion.

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