HLA-B27 subtypes in Asian patients with ankylosing spondylitis Evidence for new associations

  1. C. López-Larrea1,3,*,
  2. K. Sujirachato2,
  3. N. K. Mehra4,
  4. P. Chiewsilp2,
  5. D. Isarangkura5,
  6. U. Kanga4,
  7. O. Dominguez1,
  8. E. Coto1,
  9. M. Penã1,
  10. F. Setién3,
  11. S. Gonzalez-Roces1

Article first published online: 11 DEC 2008

DOI: 10.1111/j.1399-0039.1995.tb02436.x

Issue

Tissue Antigens

Tissue Antigens

Volume 45, Issue 3, pages 169–176, March 1995

Additional Information

How to Cite

López-Larrea, C., Sujirachato, K., Mehra, N. K., Chiewsilp, P., Isarangkura, D., Kanga, U., Dominguez, O., Coto, E., Penã, M., Setién, F. and Gonzalez-Roces, S. (1995), HLA-B27 subtypes in Asian patients with ankylosing spondylitis Evidence for new associations. Tissue Antigens, 45: 169–176. doi: 10.1111/j.1399-0039.1995.tb02436.x

Author Information

  1. 1

    Immunology, Hospital Central de Asturias, Oviedo, Spain

  2. 2

    Blood Banking & Immunohematology, Ramathidobi Hospital, Bangkok, Thailand

  3. 3

    Immunology, Universidad Complutense, Madrid, Spain

  4. 4

    Immunogenetics Unit, All India Institute of Medical Sciences, New Delhi, India

  5. 5

    Department of Orthopedics, Ramathidobi Hospital Bangkok, Thailand

*Immunologia Hospital Central E-33006 Oviedo Spain

Publication History

  1. Issue published online: 11 DEC 2008
  2. Article first published online: 11 DEC 2008
  3. Received 16 September, revised, accepted for publication 19 October 1994

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Keywords:

  • HLA-B27 subtype;
  • ankylosing spondylitis

Abstract: The aim of this study was to investigate the contribution of the different B27 subtypes to ankylosing spondylitis (AS) susceptibility. The polymerase chain reaction (PCR) in combination with the sequence-specific oligonucloetide probes (SSOs) was used to analyse the polymorphism in exon 2 and 3 of HLA-B27 in two Asian groups with different genetic HLA structures: Indian (I) and Thai (T) populations. The same number of AS patients (45) and healthy B27 positive donors (n=17) from both populations were analysed in order to ascertain the B27 subtypes. Three different findings can be concluded from this study: 1) B*2707 has been found to be associated with AS in both populations. This association has not been previously reported in either ethnic group. 2) B*2704 is strongly associated with AS in the Thai patients (91% in AS vs. 47% in C; RR=11.5; EF=0.83). In contrast, B*2704 was found with similar frequency in Asian Indians AS patients and controls (41% in AS vs. 41% in G). 3) B*2706 was found overrepresented in control populations and absent in AS patients (0% in AS vs. 47% in C; pc<10-6) showing the maximum value of protective fraction (PF=1). The B*2706 negative association with AS has not been previously described in other ethnic groups and could indicate a protective effect of this subtype on AS susceptibility. The B*2706 allele has two changes relative to B*2704 at residue 114 (His to Asp) and 116 (Asp to Tyr) in the pockets D/E. The importance that these differences can play in the pathogenesis of AS are discussed.

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