A strong association between HLA-B*5101 and Behçet's disease in Greek patients

  1. N. Mizukl1,2,
  2. S. Ohno1,
  3. H. Ando3,
  4. L. Chen2,
  5. G. D. Palimeris4,
  6. E. Stavropoulos-Ghiokas5,
  7. M. Ishihara1,
  8. K. Goto1,2,
  9. S. Nakamura1,
  10. Y. Shindo1,
  11. K. Isobe1,
  12. N. Ito1,
  13. H. Inoko2,*

Article first published online: 11 DEC 2008

DOI: 10.1111/j.1399-0039.1997.tb02835.x

Issue

Tissue Antigens

Tissue Antigens

Volume 50, Issue 1, pages 57–60, July 1997

Additional Information

How to Cite

Mizukl, N., Ohno, S., Ando, H., Chen, L., Palimeris, G. D., Stavropoulos-Ghiokas, E., Ishihara, M., Goto, K., Nakamura, S., Shindo, Y., Isobe, K., Ito, N. and Inoko, H. (1997), A strong association between HLA-B*5101 and Behçet's disease in Greek patients. Tissue Antigens, 50: 57–60. doi: 10.1111/j.1399-0039.1997.tb02835.x

Author Information

  1. 1

    Department of Ophthalmology, Yokohama City University School of Medicine, Kanagawa

  2. 2

    Department of Genetic Information, Division of Molecular Life Science, Tokai University School of Medicine, Kanagawa

  3. 3

    Kanagawa Shonan Red Cross Blood Center, Kanagawa, Japan

  4. 4

    Department of Ophthalmology, Athens University, Athens

  5. 5

    Department of Immunology and National Center of Histocompatibility, General Hospital of Athens, Greece

*Department of Genetic Information Division of Molecular Life Science Tokai University School of Medicine Bohseidai Isehara Kanagawa 259-11 Japan Fax + 81 463-94-8884 E-mail hinoko@is.icc.u-tokai.ac.jp

Publication History

  1. Issue published online: 11 DEC 2008
  2. Article first published online: 11 DEC 2008
  3. Received 7 February, accepted for publication 6 March 1997

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Keywords:

  • HLA;
  • Behçet̂s disease;
  • Greek;
  • B51;
  • genotyping;
  • PCR-SSP

Behçet's disease is known to be associated with HLA-B51, one of the split antigens of HLA-B5, among many different ethnic groups. In a Greek population, an increased incidence of HLA-B5 in the patient group also been reported. Because the B51 antigen has been recently identified to comprise seven alleles, B*5101-B*5107, we performed HLA-B51 allele genotyping by the PCR-SSP method as well as serological HLA-A and -B typing among 31 Greek patients with Behçet's disease to investigate whether there is any correlation between one particular B51-associated allele and Behçet's disease. The frequency of B51 was remarkably high (80.6%) in the patient group as compared to the ethnically matched control group (26.7%). In addition, HLA-A26 was also increased in the patients (29.0%) as compared with the healthy controls (3.3%). B51 allele genotyping revealed that all these B51-positive patients carried B*5101. This study revealed a strong association of Behçet's disease in Greeks with one of B51 subantigens, providing insight into the molecular mechanism underlying an HLA association with Behçet's disease.

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