Novel HLA-A and HLA-B alleles

  1. C.K. Hurley1,*,
  2. N. Steiner1,
  3. C. Kosman1,
  4. W. Mitton2,
  5. R. Koester3,
  6. M. Bei1,
  7. J. Bush4,
  8. J. McCormack5,
  9. A. Hahn6,
  10. V. Henson2,
  11. R. Hoyer1,
  12. J.A. Wade7,
  13. R.J. Hartzman2,
  14. J. Ng2,4

Article first published online: 11 DEC 2008

DOI: 10.1111/j.1399-0039.1998.tb03029.x

Issue

Tissue Antigens

Tissue Antigens

Volume 52, Issue 1, pages 84–87, July 1998

Additional Information

How to Cite

Hurley, C., Steiner, N., Kosman, C., Mitton, W., Koester, R., Bei, M., Bush, J., McCormack, J., Hahn, A., Henson, V., Hoyer, R., Wade, J., Hartzman, R. and Ng, J. (1998), Novel HLA-A and HLA-B alleles. Tissue Antigens, 52: 84–87. doi: 10.1111/j.1399-0039.1998.tb03029.x

Author Information

  1. 1

    Department of Microbiology and Immunology, Georgetown University Medical School, Washington DC, USA

  2. 2

    Naval Medical Research Institute, Bethesda MD, USA

  3. 3

    Laboratory Corporation of America Holdings, Burlington NC. USA

  4. 4

    Department of Pediatrics, Georgetown University Medical School, Washington DC, USA

  5. 5

    Baylor University Medical Center, Dallas TX, USA

  6. 6

    Albany Medical College, Albany NY, USA

  7. 7

    Regional Histocompatibillty Laboratory, The Toronto Hospital, University of Toronto, Toronto, Ontario M5G 2M1, Canada

*E404 Research Building Georgetown University Medical Center 3970 Reservoir Rd NW Washington DC 20007 USA Tel: 1202 687 2157 Fax: 1202 687 7505

Publication History

  1. Issue published online: 11 DEC 2008
  2. Article first published online: 11 DEC 2008
  3. Received 3 March, 1998, revised, accepted for publication 17 March 1998

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Keywords:

  • HLA-A;
  • HLA-B;
  • polymorphism

Abstract: Nine novel HLA-A and HLA-B alleles are described: A*2609, A*6803, A*6806, B*1539, B*1540, B*2712, B*4103, B*5109, and B*5603. Most appear to have arisen by gene conversion events. B*5603 appears to have arisen by a reciprocal recombination event joining exon 2 of a B*55/*56 allele with exon 3 of a B*15 allele. Serologically, the antigen encoded by this allele types with broad B22- and Bw6-specific alloantisera. Also unique, the antigen encoded by B*2712 does not react with B27-spedfic alloantisera but does react with Bw6-specifk alloantisera.

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