A. Polvi and O.A. Garden made an equal contribution to this paper and share dual first authorship.
Genetic susceptibility to gluten sensitive enteropathy in Irish setter dogs is not linked to the major histocompatibility complex
Article first published online: 11 DEC 2008
Copyright © 1998 Munksgaard
Volume 52, Issue 6, pages 543–549, December 1998
How to Cite
Polvi, A., Garden, O.A., Houlston, R.S., Maki, M., Batt, R.M. and Partanen, J. (1998), Genetic susceptibility to gluten sensitive enteropathy in Irish setter dogs is not linked to the major histocompatibility complex. Tissue Antigens, 52: 543–549. doi: 10.1111/j.1399-0039.1998.tb03085.x
- Issue published online: 11 DEC 2008
- Article first published online: 11 DEC 2008
- Received 14 July, accepted for publication 11 September 1998
- animal model;
- celiac disease;
- gluten sensitive enteropathy;
- linkage analysis;
- nucleotide sequence
Abstract: Gluten sensitive enteropathy (GSE) in Irish setter dogs has been proposed as an animal model for human celiac disease (CD), in which the major histocompatibility complex (MHC) class II alleles HLA DQAl*0501 and DQBl*0201 play an important role. To investigate whether an orthologous MHC class II region is involved in canine GSE, we undertook a linkage study in two large families of gluten sensitive Irish setter dogs. A total of 44 dogs in these pedigrees were genotyped for DQA1, DQB1 and C.2202 alleles, along with 30 unrelated healthy Irish setters. No genetic linkage between the DQ or C.2002 loci and GSE was detected. In contrast to CD, susceptibility to canine GSE does not appear to be determined by variation within the MHC class II gene cluster. Therefore, canine GSE may not be an appropriate model for CD, but nevertheless remains an important disease for advancing knowledge of pathological processes in the intestine.