Haplotype variation at the IBD5/SLC22A4 locus (5q31) in coeliac disease in the Irish population

Authors

  • A.W. Ryan,

    1. Department of Clinical Medicine, Trinity College, Trinity Center for Health Sciences, St James's Hospital, Dublin, Ireland
    2. Dublin Molecular Medicine Center, Trinity Center for Health Sciences, St James's Hospital, Dublin, Ireland
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  • J.M. Thornton,

    1. Department of Clinical Medicine, Trinity College, Trinity Center for Health Sciences, St James's Hospital, Dublin, Ireland
    2. Dublin Molecular Medicine Center, Trinity Center for Health Sciences, St James's Hospital, Dublin, Ireland
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  • K. Brophy,

    1. Department of Clinical Medicine, Trinity College, Trinity Center for Health Sciences, St James's Hospital, Dublin, Ireland
    2. Dublin Molecular Medicine Center, Trinity Center for Health Sciences, St James's Hospital, Dublin, Ireland
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  • J.S. Daly,

    1. Department of Clinical Medicine, Trinity College, Trinity Center for Health Sciences, St James's Hospital, Dublin, Ireland
    2. Dublin Molecular Medicine Center, Trinity Center for Health Sciences, St James's Hospital, Dublin, Ireland
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  • C. O'Morain,

    1. Department of Clinical Medicine, Trinity College, Trinity Center for Health Sciences, The Adelaide & Meath Hospital Dublin, Incorporating The National Children's Hospital, Dublin, Ireland
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  • R.M. McLoughlin,

    1. Department of Clinical Medicine, Trinity College, Trinity Center for Health Sciences, The Adelaide & Meath Hospital Dublin, Incorporating The National Children's Hospital, Dublin, Ireland
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  • N.P. Kennedy,

    1. Department of Clinical Medicine, Trinity College, Trinity Center for Health Sciences, St James's Hospital, Dublin, Ireland
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  • M. Abuzakouk,

    1. Department of Immunology, Trinity College, Trinity Center for Health Sciences, St James's Hospital, Dublin, Ireland
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  • F.M. Stevens,

    1. Department of Medicine, National University of Ireland, Galway, Ireland
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  • C. Feighery,

    1. Department of Immunology, Trinity College, Trinity Center for Health Sciences, St James's Hospital, Dublin, Ireland
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  • D. Kelleher,

    1. Department of Clinical Medicine, Trinity College, Trinity Center for Health Sciences, St James's Hospital, Dublin, Ireland
    2. Dublin Molecular Medicine Center, Trinity Center for Health Sciences, St James's Hospital, Dublin, Ireland
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  • R. McManus

    Corresponding author
    1. Department of Clinical Medicine, Trinity College, Trinity Center for Health Sciences, St James's Hospital, Dublin, Ireland
    2. Dublin Molecular Medicine Center, Trinity Center for Health Sciences, St James's Hospital, Dublin, Ireland
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*R. McManus
Department of Clinical Medicine, Dublin Molecular Medicine Center,
Trinity Center for Health Sciences,
St James's Hospital,
Dublin 8, Ireland
e-mail: rmcmanus@tcd.ie

Abstract

Abstract In addition to the well-established association of coeliac disease (CD) with HLA-DQ (6p21) and possibly CTLA4 (2q33), there is considerable evidence for a susceptibility locus on chromosome 5q, which contains many potential candidates for inflammatory disease, including a cluster of cytokine genes in 5q31. CD cases and controls were genotyped for four single-nucleotide polymorphism (SNP) markers that together characterize >90% of the haplotype variation at the IBD5 locus encoding, among others, the SLC22A4 gene. IBD5 and SLC22A4 map to 5q31 and have recently been associated with Crohn's disease and rheumatoid arthritis. Haplotype frequencies do not differ significantly between CD cases and controls in the Irish population, and therefore the chromosome  5 CD susceptibility locus most likely lies elsewhere on 5q.

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