Investigation of killer cell immunoglobulin-like receptor gene diversity V. KIR3DL2


*Dr Fionnuala Williams
Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory
City Hospital
Belfast BT9 7TS
Fax: +44 28 90263881


Abstract:  Allelic definition within the killer cell immunoglobulin-like receptor gene, KIR3DL2, has been achieved through a sequence-specific oligonucleotide probe methodology, designed around the specific amplification of the D0 and D1 domains and a section of the cytoplasmic tail of this gene. The system has been applied to a healthy Northern Irish control group, establishing frequencies for this Caucasian population. Additionally, the KIR3DL2 allele status of cell line DNA and Centre d'Etude du Polymorphisme Humain (CEPH) families, both from the 13th International Histocompatibility Workshop, has been established. A high level of KIR3DL2 allelic polymorphism has been identified.