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Ten novel HLA-DRB1 alleles and one novel DRB3 allele


*Carolyn Katovich Hurley, Ph.D.
E404 Research Building
Georgetown University Medical Center
3970 Reservoir Road, NW
Washington, DC 20057, USA
Tel.: +1 202 687 2157
Fax: +1 202 687 6440


Ten novel HLA-DRB1 and one DRB3 alleles are described. Eight of the variants are single-nucleotide substitutions, four resulting in an amino acid change (DRB1*1145, *1148, *0828 and *1514) and four with silent substitutions (DRB1*040504, *130103, *160502 and DRB3*020204). Two alleles differ by two nucleotide changes altering one (DRB1*1447 and *1361) amino acid and one allele alters three nucleotides and two amino acids.