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Diversity of human leukocyte antigen-B27 alleles in Han population of Hunan province, southern China
Article first published online: 6 JUL 2006
DOI: 10.1111/j.1399-0039.2006.00638.x
Additional Information
How to Cite
Ma, H.-J. and Hu, F.-P. (2006), Diversity of human leukocyte antigen-B27 alleles in Han population of Hunan province, southern China. Tissue Antigens, 68: 163–166. doi: 10.1111/j.1399-0039.2006.00638.x
Publication History
- Issue published online: 6 JUL 2006
- Article first published online: 6 JUL 2006
- Received 15 March 2006; revised 4 May 2006; accepted 4 June 2006
- Abstract
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Keywords:
- ankylosing spondylitis;
- HLA-B27;
- spondyloarthropathies;
- subtypes
Abstract
This study was to investigate the frequency of HLA-B27 and its subtypes in the Han population of Hunan province, southern China. One hundred and sixty-nine healthy unrelated donors were tested for HLA-B27 by polymerase chain reaction-sequence-specific primer (PCR-SSP). One hundred and twenty-eight B27-positive spondyloarthropathy patients and 18 B27-positive healthy controls were subtyped using the high-resolution PCR-SSP. The phenotype frequency of human leukocyte antigen (HLA)-B27 was found to be 2.36% in healthy population. Five B27 alleles were identified: B*2704, B*2705, B*2706, B*2707, and B*2724. No significant difference was found in the distribution of HLA-B27 subtypes between the patients and controls studied. Notably, B*2724 was observed in a juvenile patient with ankylosing spondylitis. This subtype has not been previously reported in Chinese ankylosing spondylitis (AS) patients and other ethnic groups.