Human leukocyte antigen class I and MICA haplotypes in a multicase family with Cladophialophora carrionii chromoblastomycosis

  1. F. Naranjo1,
  2. I. Márquez1,
  3. K. Gendzekhadze2,
  4. S. Zhang3,
  5. M. Fernández-Mestre2,
  6. F. Yegres4,
  7. N. Richard-Yegres4,
  8. T. Navas1,
  9. S. Montagnani2,
  10. V. Ogando2,
  11. Z. Layrisse2

Article first published online: 4 SEP 2006

DOI: 10.1111/j.1399-0039.2006.00666.x

Issue

Tissue Antigens

Tissue Antigens

Volume 68, Issue 4, pages 287–292, October 2006

Additional Information

How to Cite

Naranjo, F., Márquez, I., Gendzekhadze, K., Zhang, S., Fernández-Mestre, M., Yegres, F., Richard-Yegres, N., Navas, T., Montagnani, S., Ogando, V. and Layrisse, Z. (2006), Human leukocyte antigen class I and MICA haplotypes in a multicase family with Cladophialophora carrionii chromoblastomycosis. Tissue Antigens, 68: 287–292. doi: 10.1111/j.1399-0039.2006.00666.x

Author Information

  1. 1

    Postgrado de Medicina Interna, Hospital General del Oeste, Universidad Central de Venezuela, Venezuela

  2. 2

    Laboratorio de Fisiopatologia, Centro de Medicina Experimental Miguel Layrisse, Instituto Venezolano de Investigaciones Científicas, Caracas, Venezuela

  3. 3

    Department of Mathematical Sciences, Michigan Technological University, Houghton, MI 49931, USA

  4. 4

    Centro de Investigaciones Biomédicas, Universidad Nacional Experimental Francisco de Miranda, Coro, Estado Falcón, Venezuela

*Zulay Layrisse Laboratorio de Fisiopatologia Centro de Medicina Experimental Miguel Layrisse Instituto Venezolano de Investigaciones Científicas Kilómetro 11 Carretera Panamericana Apdo. 21827 Caracas 1020a Venezuela Tel: 58212 5041155 Fax: 58212 5041086 e-mail: zlayriss@ivic.ve

Publication History

  1. Issue published online: 5 OCT 2006
  2. Article first published online: 4 SEP 2006
  3. Received 5 May 2006; revised 28 June 2006; accepted 11 July 2006

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Keywords:

  • chromoblastomycosis;
  • Cladophialophora carrionii;
  • Fonsecaea pedrosoi;
  • HLA;
  • MICA

Abstract

Previous studies carried out in an endemic semiarid region northwest of Venezuela at Falcon State have shown a prevalence of 15.4/1000 of chromoblastomycosis following traumatisms with xenophile vegetation infected with Cladophialophora carrionii. We performed high-resolution DNA typing of human leukocyte antigen (HLA)-A, -B and -C and major histocompatibility complex class I chain related gene A (MICA) alleles and segregation analysis in 49 members of one extended family with 12 affected individuals, who have lived for approximately 70 years in this endemic zone. None of the alleles, haplotypes or genotypes is shared by all the patients. No deviation from the expected HLA haplotype distribution or association of chromoblastomycosis with HLA-A, -B and -C haplotypes was observed. Further, a haplotype-sharing transmission/disequilibria testing of 11 nuclear families did not give enough evidence to claim linkage (P= 0.398), suggesting that genes located in the short arm of chromosome 6 may not be relevant in the immune response toward infection with C. carrionii in this Venezuelan endemic zone. Deleted MICA alleles on HLA-B*4802 haplotypes were present among several members of the extended family, but only two of them were affected.

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