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IFNγ and CXCR-1 gene polymorphisms in idiopathic bronchiectasis

Authors

  • R. J. Boyton,

    Corresponding author
    1. Lung Immunology Group, Infection and Immunity & National Heart and Lung Institute, Sir Alexander Fleming Building, South Kensington Campus, Faculty of Medicine, Imperial College, London SW7 2AZ, UK
    2. Host Defence Unit, Department of Respiratory Medicine, Royal Brompton & Harefield NHS Trust, London SW3 6NP, UK
      Rosemary J. Boyton, MRC Clinician Scientist
      Lung Immunology Group
      Infection and Immunity & National Heart and
      Lung Institute
      Sir Alexander Fleming Building
      South Kensington Campus
      Faculty of Medicine
      Imperial College
      London SW7 2AZ
      UK
      Tel: 44 20 759 41508
      e-mail: r.boyton@imperial.ac.uk
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  • C. Reynolds,

    1. Lung Immunology Group, Infection and Immunity & National Heart and Lung Institute, Sir Alexander Fleming Building, South Kensington Campus, Faculty of Medicine, Imperial College, London SW7 2AZ, UK
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  • F. N. Wahid,

    1. Human Disease Immunogenetics Group, Department of Infectious Diseases and Immunity, Hammersmith Hospital, Imperial College, London W12 ONN, UK
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  • M. G. Jones,

    1. Department of Occupational and Environmental Medicine, NHLI, Brompton Campus, Imperial College, London SW3 6NP, UK
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  • L. Ozerovitch,

    1. Host Defence Unit, Department of Respiratory Medicine, Royal Brompton & Harefield NHS Trust, London SW3 6NP, UK
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  • T. Ahmad,

    1. Gastroenterology Unit, University of Oxford, Gibson Laboratories, Radcliffe Infirmary, Oxford OX2 6QX, UK
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  • A. Chaudhry,

    1. Department of Medicine, University of Cambridge, Addenbrooke’s Hospital Cambridge, CB2 1QQ, UK
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  • D. P. Jewell,

    1. Gastroenterology Unit, University of Oxford, Gibson Laboratories, Radcliffe Infirmary, Oxford OX2 6QX, UK
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  • O. M. Kon,

    1. Chest and Allergy Department, St Mary’s Hospital NHS Trust, London W2 1NY, UK
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  • J. Smith,

    1. Heart Science Centre, Harefield Hospital, Imperial College, Harefield, Middx UB9 6JH, UK
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  • M. Rose,

    1. Heart Science Centre, Harefield Hospital, Imperial College, Harefield, Middx UB9 6JH, UK
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  • A. J. Newman-Taylor,

    1. Department of Occupational and Environmental Medicine, NHLI, Brompton Campus, Imperial College, London SW3 6NP, UK
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  • P. Cole,

    1. Host Defence Unit, Department of Respiratory Medicine, Royal Brompton & Harefield NHS Trust, London SW3 6NP, UK
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  • R. Wilson,

    1. Host Defence Unit, Department of Respiratory Medicine, Royal Brompton & Harefield NHS Trust, London SW3 6NP, UK
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  • D. M. Altmann

    1. Human Disease Immunogenetics Group, Department of Infectious Diseases and Immunity, Hammersmith Hospital, Imperial College, London W12 ONN, UK
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Rosemary J. Boyton, MRC Clinician Scientist
Lung Immunology Group
Infection and Immunity & National Heart and
Lung Institute
Sir Alexander Fleming Building
South Kensington Campus
Faculty of Medicine
Imperial College
London SW7 2AZ
UK
Tel: 44 20 759 41508
e-mail: r.boyton@imperial.ac.uk

Abstract

Idiopathic bronchiectasis is a disease of chronic, bacterial lung infection, unresolving inflammation and progressive lung damage. Bronchiectasis can be associated with autoimmune diseases including ulcerative colitis. Defects of both innate and adaptive immunity have been proposed. The airway inflammation is characterized by interleukin-8 (IL-8) expression and infliltration by neutrophils and T cells. Here we investigated two candidate gene polymorphisms that may contribute to disease susceptibility: a CXCR-1 (+2607 G/C) gene polymorphism that is implicated in IL-8 binding and neutrophil trafficking as well as the interferon-γ (IFNγ) (+874 T/A) polymorphism which is linked to levels of IFNγ production. These polymorphisms were distributed similarly in the idiopathic bronchiectasis group and controls, suggesting that these two candidate gene polymorphisms are not associated with disease susceptibility.

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