The LRC haplotype project: a resource for killer immunoglobulin-like receptor-linked association studies

  1. R. Horton1,
  2. P. Coggill1,
  3. M. M. Miretti1,
  4. J. G. Sambrook1,
  5. J. A. Traherne2,
  6. R. Ward2,
  7. S. Sims1,
  8. S. Palmer1,
  9. H. Sehra1,
  10. J. Harrow1,
  11. J. Rogers1,
  12. M. Carrington3,
  13. J. Trowsdale2,
  14. S. Beck1,*

Article first published online: 7 NOV 2006

DOI: 10.1111/j.1399-0039.2006.00697.x

Issue

Tissue Antigens

Tissue Antigens

Volume 68, Issue 5, pages 450–452, November 2006

Additional Information

How to Cite

Horton, R., Coggill, P., Miretti, M. M., Sambrook, J. G., Traherne, J. A., Ward, R., Sims, S., Palmer, S., Sehra, H., Harrow, J., Rogers, J., Carrington, M., Trowsdale, J. and Beck, S. (2006), The LRC haplotype project: a resource for killer immunoglobulin-like receptor-linked association studies. Tissue Antigens, 68: 450–452. doi: 10.1111/j.1399-0039.2006.00697.x

Author Information

  1. 1

    Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge CB10 1SA, UK

  2. 2

    Department of Pathology, Immunology Division, University of Cambridge CB2 1QP, Cambridge, UK

  3. 3

    Laboratory of Genomic Diversity, SAIC-Frederick, Inc., NCI-Frederick, Frederick, MD 21702, USA

*S. Beck Wellcome Trust Sanger Institute Genome Campus, Hinxton Cambridge CB10 1SA UK Tel: 44 1223 494952 Fax: 44 1223 494919 e-mail: beck@sanger.ac.uk

Publication History

  1. Issue published online: 7 NOV 2006
  2. Article first published online: 7 NOV 2006
  3. Received 1 September 2006; accepted 11 September 2006

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Keywords:

  • haplotypes;
  • killer immunoglobulin-like receptor;
  • leucocyte receptor complex;
  • polymorphism;
  • single nucleotide

Abstract

There is increasing evidence for epistatic interactions between gene products (e.g. KIR) encoded within the Leukocyte Receptor Complex (LRC) with those (e.g. HLA) of the Major Histocompatibility Complex (MHC), resulting in susceptibility to disease. Identification of such associations at the DNA level requires comprehensive knowledge of the genetic variation and haplotype structure of the underlying loci. The LRC haplotype project aims to provide this knowledge by sequencing common LRC haplotypes.

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