Polymorphisms of human leucocyte antigen genes in Maonan people in China


Prof. Jia You Chu
Institute of Medical Biology
Chinese Academy of Medical Science
Kunming 650118
Tel: 86-871-8334326
Fax: 86-871-8334483
e-mail: chujy@imbcams.com.cn
Prof. Katsushi Tokunaga
Department of Human Genetics
Graduate School of Medicine
University of Tokyo
Tokyo 113-0033
Tel: +81-3-5841-3692
Fax: +81-3-5802-2907
e-mail: tokunaga@m.u-tokyo.ac.jp


We examined human leucocyte antigen (HLA) gene polymorphisms in the Maonan people from southern China. HLA-A, -B and -DRB1 alleles were determined in 108 healthy unrelated Maonan individuals by the polymerase chain reaction-Luminex method, and haplotype frequencies for HLA-A, -B and -DRB1 loci were estimated. The most frequent HLA-A alleles were A*1101 (35.2%), A*0203 (17.6%), A*0207 (13.4%) and A*2402 (13.4%); HLA-B alleles were B*1301(19.9%), B*1502 (14.8%), B*4601 (13.4%) and B*4001 (13.4%); HLA-DRB1 alleles were DRB1*1202 (17.1%), DRB1*1602 (13.0%) and DRB1*1401 (10.7%). The most common haplotypes were A*0207-B*4601 (10.6%), A*1101-B*1301 (10.0%), A*1101-B*4001 (8.4%), B*1502-DRB1*1202 (12.0%), B*4601-DRB1*1401 (5.8%), A*1101-B*1502-DRB1*1202 (7.1%) and A*0207-B*4601-DRB1*1401 (5.3%), profiles that are also found in populations from the southern region of East Asia. Phylogenetic and principal component analyses revealed that the Maonan people belong to the southeastern Asian group and are most closely related to the Buyi people.