14th International HLA and Immunogenetics Workshop: Report on the structural basis of HLA compatibility

Authors

  • R. J. Duquesnoy,

    Corresponding author
    1. Division of Transplantation Pathology, Thomas E. Starzl Transplantation Institute, University of Ptttsburgh Medical Center, Pittsburgh, PA, USA
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  • F. H. J. Claas

    1. Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, the Netherlands
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Rene J. Duquesnoy, PhD
Professor of Pathology, Immunology and Surgery
University of Pittsburgh Medical Center
Thomas E. Starzl Biomedical Science Tower, Room W1552
Pittsburgh
PA 15261
USA
Tel: 1 412 647 6148; Mobile: 1 412 860 8083
Fax: 1 412 647 1755
e-mail: duquesnoyr@msx.upmc.edu

Abstract

Under auspices of the 14th International Human Leukocyte Antigen (HLA) and Immunogenetics Workshop, multilaboratory collaborative studies were organized addressing the following projects: (1) identification of structurally defined class I and class II HLA epitopes by human monoclonal antibodies, (2) assessment of the relative immunogenicity of structurally defined donor HLA mismatches in kidney transplantation, and (3) evaluation of the usefulness of structurally based HLA matching in platelet transfusion support of alloimmunized thrombocytopenic patients. This progress report describes a preliminary HLAMatchmaker-based data analysis in each project. The findings support the clinical usefulness of structural HLA matching.

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