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MHC class I, II, and III microsatellite marker matching and survival in unrelated donor hematopoietic cell transplantation


Marri Malkki, PhD
Fred Hutchinson Cancer Research Center
1100 Fairview Ave N D4-100
Seattle, WA 98109
Tel: +1 206 667 5797
Fax: +1 206 667 2917


Microsatellites (Msats) are effective markers for disease association mapping. The International Histocompatibility Working Group in hematopoietic cell transplantation applied Msats to determine whether potential new transplantation determinants are encoded within the major histocompatibility complex. Retrospective analysis of human leukocyte antigen-identical unrelated donor transplants provided a homogeneous population to measure Msat-associated risks of mortality.