Get access

The identification and characterisation of a novel null HLA-DRB1 allele

Authors

  • S. J. Fidler,

    1. Department of Clinical Immunology and Biochemical Genetics, Pathwest Royal Perth Hospital, Perth, WA, Australia
    Search for more papers by this author
  • L. K. Smith,

    1. Department of Clinical Immunology and Biochemical Genetics, Pathwest Royal Perth Hospital, Perth, WA, Australia
    Search for more papers by this author
  • F. T. Christiansen

    Corresponding author
    1. Department of Clinical Immunology and Biochemical Genetics, Pathwest Royal Perth Hospital, Perth, WA, Australia
    2. School of Surgery and Pathology, University of Western Australia, Nedlands, WA, Australia
    Search for more papers by this author

F. T. Christiansen
Department of Clinical Immunology
Pathwest
Royal Perth Hospital
GPO Box X2213
Perth
Tel: 61 8 9224 2683
Fax: 61 8 9224 2920
e-mail: ftchrist@cyllene.uwa.edu.au

Abstract

Since the introduction of DNA-based human leukocyte antigen (HLA) typing a number of discrepancies with serological typing have been documented. At the time of submission of this abstract (July 2005 ImMunoGeneTics project (IMGT) project database release) 42 HLA class I and II null alleles had been described characterised by a lack of expression of cell surface antigen. These null alleles can be accounted for by a number of demonstrated molecular mechanisms including insertion, deletion and point mutation and may lead to a nonsense codon, splicing defect or premature stop codon.

Ancillary