Both contributed equally as senior authors.
Increased frequencies of activating natural killer receptors are associated with liver injury in individuals who do not eliminate hepatitis C virus
Article first published online: 13 APR 2007
2007 Blackwell Munksgaard
Volume 69, Issue Supplement s1, pages 109–111, April 2007
How to Cite
Paladino, N., Flores, A. C., Marcos, C. Y., Fainboim, H., Theiler, G., Arruvito, L., Williams, F., Middleton, D. and Fainboim, L. (2007), Increased frequencies of activating natural killer receptors are associated with liver injury in individuals who do not eliminate hepatitis C virus. Tissue Antigens, 69: 109–111. doi: 10.1111/j.1399-0039.2006.762_7.x
- Issue published online: 13 APR 2007
- Article first published online: 13 APR 2007
- hepatitis C virus;
- killer immunoglobulin-like receptor;
- natural killer cells
This study was designed to investigate the role of killer immunoglobulin-like receptor (KIR) genes in the outcome of hepatitis C virus (HCV) infection. In patients who cleared the virus (HCV RNA−) we found a decrease of 2DL2 (P= 0.04), and 2DS2 (P= 0.014) accompanied by an increase of 2DS5 (P= 0.04). Those RNA+ patients with elevated levels of hepatic transaminases (HCV RNA+ elevated alanine aminotransferase) showed an increased frequency of 2DS3 (P= 0.018). Additionally, in cirrhotic patients we found an increased frequency of individuals having two copies of 3DS1 and HLA-Bw4 (P= 0.016). We conclude that higher natural killer cytotoxicity might be associated with a worse progression of the HCV infection.