Increased frequencies of activating natural killer receptors are associated with liver injury in individuals who do not eliminate hepatitis C virus

Authors

  • N. Paladino,

    1. División Inmunogenética, Hospital de Clínicas ‘José de San Martín’, Facultad de Medicina, Universidad de Bueno Aires, Buenos Aires, Argentina
    2. Departamento de Microbiología, Parasitología e Inmunología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina
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  • A. C. Flores,

    1. División Inmunogenética, Hospital de Clínicas ‘José de San Martín’, Facultad de Medicina, Universidad de Bueno Aires, Buenos Aires, Argentina
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  • C. Y. Marcos,

    1. División Inmunogenética, Hospital de Clínicas ‘José de San Martín’, Facultad de Medicina, Universidad de Bueno Aires, Buenos Aires, Argentina
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  • H. Fainboim,

    1. Unidad de Hepatología, Hospital de Enfermedades Infecciosas F. J. Muñiz, Buenos Aires, Argentina
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  • G. Theiler,

    1. División Inmunogenética, Hospital de Clínicas ‘José de San Martín’, Facultad de Medicina, Universidad de Bueno Aires, Buenos Aires, Argentina
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  • L. Arruvito,

    1. División Inmunogenética, Hospital de Clínicas ‘José de San Martín’, Facultad de Medicina, Universidad de Bueno Aires, Buenos Aires, Argentina
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  • F. Williams,

    1. Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, City Hospital, Belfast, Northern Ireland
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  • D. Middleton,

    1. Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, City Hospital, Belfast, Northern Ireland
    2. University of Ulster, Coleraine, Northern Ireland
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    • *

      Both contributed equally as senior authors.

  • L. Fainboim

    Corresponding author
    1. División Inmunogenética, Hospital de Clínicas ‘José de San Martín’, Facultad de Medicina, Universidad de Bueno Aires, Buenos Aires, Argentina
    2. Departamento de Microbiología, Parasitología e Inmunología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina
      Leonardo Fainboim
      División Inmunogenética
      Hospital de Clínicas ‘José de San Martín’
      Facultad de Medicina
      Universidad de Buenos Aires
      Av. Córdoba 2351 (1120)
      Buenos Aires
      Argentina
      Tel: 54 11 5950 8756
      Fax: 54 11 5950 8758
      e-mail: lfainboim@hospitaldeclinicas.uba.ar
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    • *

      Both contributed equally as senior authors.


Leonardo Fainboim
División Inmunogenética
Hospital de Clínicas ‘José de San Martín’
Facultad de Medicina
Universidad de Buenos Aires
Av. Córdoba 2351 (1120)
Buenos Aires
Argentina
Tel: 54 11 5950 8756
Fax: 54 11 5950 8758
e-mail: lfainboim@hospitaldeclinicas.uba.ar

Abstract

This study was designed to investigate the role of killer immunoglobulin-like receptor (KIR) genes in the outcome of hepatitis C virus (HCV) infection. In patients who cleared the virus (HCV RNA−) we found a decrease of 2DL2 (P= 0.04), and 2DS2 (P= 0.014) accompanied by an increase of 2DS5 (P= 0.04). Those RNA+ patients with elevated levels of hepatic transaminases (HCV RNA+ elevated alanine aminotransferase) showed an increased frequency of 2DS3 (P= 0.018). Additionally, in cirrhotic patients we found an increased frequency of individuals having two copies of 3DS1 and HLA-Bw4 (P= 0.016). We conclude that higher natural killer cytotoxicity might be associated with a worse progression of the HCV infection.

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