KIR receptors and HLA-C in the maintenance of pregnancy

Authors


Leonardo Fainboim
División Inmunogenética
Hospital de Clínicas ‘José de San Martín’
Facultad de Medicina
Universidad de Buenos Aires
Av. Córdoba 2351 (1120)
Buenos Aires
Argentina
Tel: 54 11 5950 8756
Fax: 54 11 5950 8758
e-mail: lfainboim@hospitaldeclinicas.uba.ar

Abstract

The present study demonstrated that patients who have recurrent spontaneous abortions (RSA) presented a decreased number of killer immunoglobulin-like inhibitory receptors (KIR), in particular KIR2DL2. The KIR AA genotype was found increased in comparison with controls. Individuals AA will also be homozygous for 2DL3, which in contrast to 2DL2, show a weaker interaction with C1 ligands and therefore a weaker inhibition. The present study might support that in RSA patients, the balance between inhibitory and activating receptors present in natural killer cells is inclined toward an activating state that may contribute to pregnancy loss.

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