Get access

Functions of HLA-G in the immune system

Authors

  • B. Favier,

    1. Service de Recherches en Hemato-Immunologie, Direction des Sciences du Vivant, Departement de Recherche Medicale, Commissariat a l‘Energie Atomique, Institut Universitaire d’Hematologie, Hopital Saint-Louis, Paris, France
    Search for more papers by this author
  • J. LeMaoult,

    1. Service de Recherches en Hemato-Immunologie, Direction des Sciences du Vivant, Departement de Recherche Medicale, Commissariat a l‘Energie Atomique, Institut Universitaire d’Hematologie, Hopital Saint-Louis, Paris, France
    Search for more papers by this author
  • E. D. Carosella

    Corresponding author
    1. Service de Recherches en Hemato-Immunologie, Direction des Sciences du Vivant, Departement de Recherche Medicale, Commissariat a l‘Energie Atomique, Institut Universitaire d’Hematologie, Hopital Saint-Louis, Paris, France
    Search for more papers by this author

Edgardo Carosella
Service de Recherches en Hemato-Immunologie
Direction des Sciences du Vivant
Departement de Recherche Medicale
Commissariat a l‘Energie Atomique
Institut Universitaire d’Hematologie
Hopital Saint-Louis
75010 Paris
France
Tel: 33(0) 153722199
Fax: 33(0) 148031960
e-mail: carosella@dsvidf.cea.fr

Abstract

Human leukocyte antigen (HLA)-G is a nonclassical HLA class I molecule that has tolerogenic functions and acts on cells of both innate and adaptive immunity. The molecular mechanism leading to tolerance involves the interaction between HLA-G and inhibitory receptors that are expressed at the surface of immune cells. In this review, we will briefly summarize the key advances on the relationships between HLA-G and the immune system and their consequences in pathology.

Ancillary