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HLA-G polymorphism and evolution

Authors

  • A. Arnaiz-Villena,

    Corresponding author
    1. Department of Immunology, The Madrid Regional Blood Center, Universidad Complutense, Madrid, Spain
      Antonio Arnaiz-Villena
      Departamento de Inmunologia
      Facultad de Medicina
      Universidad Complutense
      Avda. Complutense s/n
      28040 Madrid
      Spain
      Tel: 34 913 941632
      Fax: 34 913 017213
      e-mail: aarnaiz@med.ucm.es
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  • J. Martinez-Laso,

    1. Department of Immunology, The Madrid Regional Blood Center, Universidad Complutense, Madrid, Spain
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  • J. I. Serrano-Vela,

    1. Department of Immunology, The Madrid Regional Blood Center, Universidad Complutense, Madrid, Spain
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  • R. Reguera,

    1. Department of Immunology, The Madrid Regional Blood Center, Universidad Complutense, Madrid, Spain
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  • J. Moscoso

    1. Department of Immunology, The Madrid Regional Blood Center, Universidad Complutense, Madrid, Spain
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Antonio Arnaiz-Villena
Departamento de Inmunologia
Facultad de Medicina
Universidad Complutense
Avda. Complutense s/n
28040 Madrid
Spain
Tel: 34 913 941632
Fax: 34 913 017213
e-mail: aarnaiz@med.ucm.es

Abstract

Six proteins, one null allele and 22 human leukocyte antigen (HLA)-G alleles were found in humans. Bonobo, chimpanzee and gorilla only show one allele and orangutan shows five alleles. All Cercopithecus alleles show stop codons at position 164 (Macaca mulatta with seven DNA alleles, Macaca fascicularis with seven DNA alleles and Cercopithecus aethiops with three DNA alleles). Cotton-top tamarin New World monkeys showed 20 DNA and protein alleles; the major histocompatibility complex (MHC)-G New World sequences seem to be closer to MHC-E and lack typical MHC-G primates intron 2-specific deletion. This seems to suggest that MHC-G genes in New World primates are not orthologous and that their function may be similar to that of classical presenting MHC genes.

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