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Twenty-three novel alleles increase diversity at the HLA-C locus

  1. A. M. Lazaro1,
  2. Y. Xiao1,
  3. K. Cao1,
  4. C. Masaberg1,
  5. L. Nichol2,
  6. J. Ng1,
  7. C. K. Hurley1,
  8. P. E. Posch1,*

Article first published online: 31 MAR 2008

DOI: 10.1111/j.1399-0039.2008.01039.x

Issue

Tissue Antigens

Tissue Antigens

Volume 71, Issue 6, pages 560–563, June 2008

Additional Information

How to Cite

Lazaro, A. M., Xiao, Y., Cao, K., Masaberg, C., Nichol, L., Ng, J., Hurley, C. K. and Posch, P. E. (2008), Twenty-three novel alleles increase diversity at the HLA-C locus. Tissue Antigens, 71: 560–563. doi: 10.1111/j.1399-0039.2008.01039.x

Author Information

  1. 1

    Departments of Oncology and Pediatrics, C.W. Bill Young Marrow Donor Research and Recruitment Program, Georgetown University Medical Center, Washington, DC, USA

  2. 2

    Children Hospital of Pittsburgh Histocompatibility Center, Pittsburgh, PA, USA

*P. E. Posch, PhD Department of Oncology Georgetown University Medical Center E404 Research Building 3970 Reservoir Road, NW Washington, DC 20057 USA Tel: +1 202 687 9239 Fax: +1 202 687 6440 e-mail: poschp@georgetown.edu

Publication History

  1. Issue published online: 31 MAR 2008
  2. Article first published online: 31 MAR 2008
  3. Received 15 February 2008; revised 28 February 2008; accepted 8 March 2008

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Keywords:

  • DNA sequencing;
  • HLA-Cw;
  • new alleles

Abstract

Twenty-three novel HLA-C alleles are described. Nine of the new alleles are single-nucleotide substitutions from their most homologous allele of which seven result in amino acid changes (Cw*0327, *0508, *0514, *0613, *0735, *0739 and *1517) and two are silent substitutions (Cw*030305 and *070107). The remaining 14 alleles (Cw*0113, *0207, *0212, *0216, *0318, *0411, *0417, *0512, *0722, *0733N, *1216, *1218, *1515 and *1607) differ from their most similar alleles by 2–4 nucleotide substitutions that result in 1–3 amino acid differences.

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