The role of serpins in vertebrate immunity


Phillip Ian Bird
Building 13B
Department of Biochemistry and Molecular Biology
Monash University
Clayton, VIC 3800
Tel: +61 3 9905 3771
Fax: +61 3 9905 3726


Serine proteases are important components of the immune system, playing a role in many processes including migration, phagocytosis and elimination of virally infected and cancerous cells. Members of the serpin superfamily regulate the activity of these proteases to limit tissue damage and unwarranted cell death. This review focuses on the role of intracellular (clade B) serpins in maintaining viability of both innate and adaptive immune cells.