Association between killer-cell immunoglobulin-like receptor genotypes and leprosy in Brazil

  1. D. S. A. Franceschi1,
  2. P. S. Mazini1,
  3. C. C. C. Rudnick1,
  4. A. M. Sell1,
  5. L. T. Tsuneto1,
  6. F. C. De Melo1,
  7. M. A. Braga1,
  8. P. R. F. Peixoto2,
  9. J. E. L. Visentainer1,*

Article first published online: 5 SEP 2008

DOI: 10.1111/j.1399-0039.2008.01127.x

Issue

Tissue Antigens

Tissue Antigens

Volume 72, Issue 5, pages 478–482, November 2008

Additional Information

How to Cite

Franceschi, D. S. A., Mazini, P. S., Rudnick, C. C. C., Sell, A. M., Tsuneto, L. T., De Melo, F. C., Braga, M. A., Peixoto, P. R. F. and Visentainer, J. E. L. (2008), Association between killer-cell immunoglobulin-like receptor genotypes and leprosy in Brazil. Tissue Antigens, 72: 478–482. doi: 10.1111/j.1399-0039.2008.01127.x

Author Information

  1. 1

    Laboratório de Imunogenética, Departamento de Análises Clínicas, Universidade Estadual de Maringá, Maringá, Brazil

  2. 2

    15a Regional de Saúde da Secretaria de Saúde do Estado do Paraná, Maringá, Brazil

*Dr Jeane E. L. Visentainer Laboratório de Imunogenética Departamento de Análises Clínicas Universidade Estadual de Maringá Av. Colombo, 5790 Maringá, PR 87020-900 Brazil Tel: +55 44 3261 4864 Fax: +55 44 3261 4931 e-mail: jelvisentainer@uem.br, jelvisentainer@gmail.com

Publication History

  1. Issue published online: 16 OCT 2008
  2. Article first published online: 5 SEP 2008
  3. Received 11 April 2008; revised 22 June 2008, 9 July 2008; accepted 1 August 2008

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Keywords:

  • HLA class I;
  • KIR genes;
  • leprosy;
  • natural killer cell

Abstract

The aim of this study was to investigate the role of killer cell immunoglobulin-like receptor (KIR) genes in leprosy immunopathogenesis. Genotyping of KIR and human leukocyte antigen (HLA) genes was performed by polymerase chain reaction with sequence-specific oligonucleotide probes in 165 leprosy patients. Both activating KIR2DS2 and KIR2DS3 frequencies were higher in tuberculoid leprosy (TT) patients than in lepromatous leprosy (LL) patients, and the inhibitory KIR with its ligand, KIR2DL1-C2/C2, was elevated in TT patients in comparison to all other leprosy subgroups and controls. However, a negative association between KIR2DL3-C1 and KIR2DL3-C1/C1 and the TT group was identified. Borderline patients exhibited a higher frequency of KIR3DL2-A3/11 than the controls and LL patients, and a lower frequency of KIR2DL1-C2 than the controls and TT subgroup. Some KIR–HLA genotypes could be associated to the development of clinical forms of leprosy and should be investigated further.

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