A bioinformatics approach to ascertaining the rarity of HLA alleles

  1. D. Middleton1,*,
  2. F. Gonzalez1,
  3. M. Fernandez-Vina2,
  4. J.-M. Tiercy3,
  5. S. G. E. Marsh4,
  6. M. Aubrey5,
  7. M. G. Bicalho6,
  8. A. Canossi7,
  9. V. Carter8,
  10. S. Cate9,
  11. F. R. Guerini10,
  12. P. Loiseau11,
  13. M. Martinetti12,
  14. M. E. Moraes13,
  15. V. Morales14,
  16. J. Perasaari15,
  17. M. Setterholm22,
  18. M. Sprague16,
  19. S. Tavoularis17,
  20. M. Torres18,
  21. S. Vidal19,
  22. C. Witt20,
  23. G. Wohlwend16,
  24. K. L. Yang21

Article first published online: 29 SEP 2009

DOI: 10.1111/j.1399-0039.2009.01361.x

Issue

Tissue Antigens

Tissue Antigens

Volume 74, Issue 6, pages 480–485, December 2009

Additional Information

How to Cite

Middleton, D., Gonzalez, F., Fernandez-Vina, M., Tiercy, J.-M., Marsh, S. G. E., Aubrey, M., Bicalho, M. G., Canossi, A., Carter, V., Cate, S., Guerini, F. R., Loiseau, P., Martinetti, M., Moraes, M. E., Morales, V., Perasaari, J., Setterholm, M., Sprague, M., Tavoularis, S., Torres, M., Vidal, S., Witt, C., Wohlwend, G. and Yang, K. L. (2009), A bioinformatics approach to ascertaining the rarity of HLA alleles. Tissue Antigens, 74: 480–485. doi: 10.1111/j.1399-0039.2009.01361.x

Author Information

  1. 1

    Transplant Immunology, Royal Liverpool University Hospital and School of Infection and Host Defence, University of Liverpool, Liverpool, UK

  2. 2

    M.D. Anderson Cancer Center, HLA Typing Laboratory, Houston, TX, USA

  3. 3

    LNRH, Transplantation Immunology Unit, University Hospital Geneva, Geneva, Switzerland

  4. 4

    Anthony Nolan Research Institute, Hampstead, London, UK

  5. 5

    Division of Allergy and Clinical Immunology, ClinImmune Labs, Aurora, CO, USA

  6. 6

    Laboratório de Imunogenética e Histocompatibilidade, Departamento de Genética, Universidade Federal do Paraná, Curitiba, Brazil

  7. 7

    CNR Institute Organ Transplants and Immunocitology, L’Aquila, Italy

  8. 8

    Histocompatibility and Immunogenetics, National Blood Service, Newcastle upon Tyne, UK

  9. 9

    Microbiology, University of Oklahoma Health Service Center, Oklahoma City, OK, USA

  10. 10

    Laboratory of Molecular Medicine and Biotechnology, Don C. Gnocchi Foundation IRCCS, Milan, Italy

  11. 11

    Service d’Immunologie et Histocompatibilité, Hôpital Saint-Louis, AP-HP Paris, France

  12. 12

    HLA Laboratory, Transfusion Medicine Department, Foundation IRCSS Policlinico San Matteo, Pavia, Italy

  13. 13

    Laboratório de Imunogenética do Instituto Nacional do Câncer, Rio de Janeiro, Brazil

  14. 14

    Stem Cell Registry, INCUCAI, Buenos Aires, Argentina

  15. 15

    Department of Tissue Typing, Finnish Red Cross Blood Service, Helsinki, Finland

  16. 16

    Clinical Immunogenetics, Seattle Cancer Care Alliance, Seattle, WA, USA

  17. 17

    Head office, Canadian Blood Services, Ottawa, Canada

  18. 18

    HLA Laboratory, Albert Einstein Hospital, Sao Paulo, Brazil

  19. 19

    Department of Immunology, Hospital Sant Pau, Barcelona, Spain

  20. 20

    Department of Clinical Immunology, Royal Perth Hospital, Perth, Australia

  21. 21

    Immunogenetics Laboratory and Cord Blood Bank, Taiwan Tzu Chi Marrow Donor Registry, Hualien, Taiwan

  22. 22

    National Marrow Donor Programme, Minneapolis, MI, USA

*Prof Derek Middleton Prescott Street Liverpool L78XW UK Tel: +44 15 1706 4246 Fax: +44 15 1706 5862 e-mail: derek.middleton@rlbuht.nhs.uk

Publication History

  1. Issue published online: 6 NOV 2009
  2. Article first published online: 29 SEP 2009
  3. Received 24 May 2009;revised 16 July 2009;accepted 31 July 2009

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Keywords:

  • allele;
  • human leukocyte antigen;
  • rare

Abstract

A project of the 15th International Histocompatibility Workshop examined the rarity of human leukocyte antigen (HLA) alleles. A section was constructed in the website, www.allelefrequencies.net to contain this data from different sources. A mechanism to search the data was implemented for use by any individual.

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