Simplified procedure for carrying out simultaneous multiple hydrogen fluoride cleavages of protected peptide resins
Article first published online: 12 JAN 2009
© 1986 Munksgaard International Publishers Ltd.
International Journal of Peptide and Protein Research
Volume 27, Issue 6, pages 673–678, June 1986
How to Cite
HOUGHTEN, R. A., BRAY, M. K., DEGRAW, S. T. and KIRBY, C. J. (1986), Simplified procedure for carrying out simultaneous multiple hydrogen fluoride cleavages of protected peptide resins. International Journal of Peptide and Protein Research, 27: 673–678. doi: 10.1111/j.1399-3011.1986.tb01064.x
- Issue published online: 12 JAN 2009
- Article first published online: 12 JAN 2009
- Received 16 August, accepted 3 October 1985
- hydrogen fluoride;
- multiple cleavages;
Methods have recently been presented which greatly increase the ability to synthesize large numbers of peptides. These advances make it essential to be able to cleave large numbers of protected peptide resins. Two different procedures are presented for carrying out cleavage of protected peptide resins. The first procedure enables multiple cleavages to be carried out with many existing HF apparatuses, while the second utilizes a new apparatus design. Using these procedures, at least 50 individual cleavages can be carried out per day.