In grateful memory of Murray Goodman as a great scientist and pioneer of photomodulation of conformational transitions of polypeptides.
Azobenzene as photoresponsive conformational switch in cyclic peptides†
Article first published online: 7 JAN 2005
The Journal of Peptide Research
Volume 65, Issue 1, pages 4–14, January 2005
How to Cite
Renner, C., Kusebauch, U., Löweneck, M., Milbradt, A.G. and Moroder, L. (2005), Azobenzene as photoresponsive conformational switch in cyclic peptides. The Journal of Peptide Research, 65: 4–14. doi: 10.1111/j.1399-3011.2004.00203.x
- Issue published online: 5 DEC 2008
- Article first published online: 7 JAN 2005
- Dates: Received 29 September 2004 Revised 25 October 2004 Accepted 7 November 2004
- ω-amino azobenzenecarboxylic acids;
- biophysical properties;
- conformational switches;
- cyclic peptides;
Abstract: Over the last decades azobenzene has been the most widely used optical trigger for the synthesis of photoresponsive systems ranging from poly-α-amino acids to innovative materials with light-controlled mechanical and optical properties. More recently, its use in form of appropriate derivatives allowed to generate cyclic peptide structures of constraint conformational space and thus to exploit its reversible photoisomerization to induce well defined transitions between different conformational states. These can be characterized in detail in both photostationary states making such systems ideal substrates for ultrafast spectroscopic analysis of conformational transitions. Moreover, the changes in biophysical properties that occur as a consequence of the different conformational states can be exploited for a photo-control of a large variety of molecular recognition processes.