Parity among atopic and non-atopic mothers

Authors

  • Lennart Nilsson,

    Corresponding author
    1. Department of Health and Environment, Division of Paediatrics Linköping University, Centre for Public Health Sciences, Linköping, Sweden
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  • N-L Max Kjellman,

    1. Department of Health and Environment, Division of Paediatrics Linköping University, Centre for Public Health Sciences, Linköping, Sweden
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  • Owe Löfman,

    1. Department of Community and Environmental Medicine, Centre for Public Health Sciences, Linköping, Sweden
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  • Bengt Björkstén

    1. Department of Health and Environment, Division of Paediatrics Linköping University, Centre for Public Health Sciences, Linköping, Sweden
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Dr Lennart Nilsson, M. D., Department of Health and Environment, Division of Paediatrics, Linköping University, S-581 85 Linköping, Sweden

Abstract

A temporary Th2 skewed immunity is essential for a successful outcome of pregnancy. It is also a hallmark of atopic disease. We recorded the number of siblings to 3667 children in relation to maternal atopy. In all, 65% of the allergic and 56% of the non-allergic mothers had more than one child (p < 0.001). These data support a hypothesis that the atopic genotype may be associated with an increased likelihood for a successful outcome of pregnancy and thus from an evolutionary point of view compensate for the less efficient host defence against microbial infections associated with this type of immunity.

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