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House dust mite allergen reduction and allergy at 4 yr: Follow up of the PIAMA-study

Authors

  • Karen Corver,

    1. Department of Pediatrics, Division of Respiratory Medicine, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands
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  • Marjan Kerkhof,

    1. Department of Pediatrics/Respiratory Medicine, University Hospital Groningen, Groningen, The Netherlands
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  • Jessica E. Brussee,

    1. Centre for Prevention and Health Services Research, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
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  • Bert Brunekreef,

    1. Institute for Risk Assessment Sciences, Faculties of Veterinary Medicine, Science and University Medical Centre Utrecht, University of Utrecht, Utrecht, The Netherlands
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  • Rob T. Van Strien,

    1. Institute for Occupational and Environmental Medicine, Unit for Occupational and Environmental Epidemiology & Net Teaching, Ludwig-Maximilians-University, Munich, Germany
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  • Ada P. Vos,

    1. Institute for Risk Assessment Sciences, Faculties of Veterinary Medicine, Science and University Medical Centre Utrecht, University of Utrecht, Utrecht, The Netherlands
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  • Henriette A. Smit,

    1. Centre for Prevention and Health Services Research, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
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  • Jorrit Gerritsen,

    1. Department of Pediatrics/Respiratory Medicine, University Hospital Groningen, Groningen, The Netherlands
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  • Herman J. Neijens,

    1. Department of Pediatrics, Division of Respiratory Medicine, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands
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    • Prof. Herman Neijens deceased in 2004.

  • Johan C. De Jongste

    1. Department of Pediatrics, Division of Respiratory Medicine, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands
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Prof. Johan C. de Jongste, Department of Pediatrics/Respiratory Medicine, Erasmus University Medical Centre/Sophia Children's Hospital, PO Box 2060, 3000 CB Rotterdam, The Netherlands
Tel.: +31 10 463 6263
Fax: +31 10 463 6811
E-mail: j.c.dejongste@erasmusmc.nl

Abstract

Exposure to high allergen levels in early life is a risk factor for the development of allergy. We previously reported limited effects of mite allergen impermeable mattress covers in the prevention and incidence of asthma and mite allergy (PIAMA) cohort at the age of 1 and 2 yr. We now present the results of follow-up at 4 yr objectives. To examine the effects of early reduction of house dust mite (HDM) allergen exposure by means of mattress covers on the incidence of allergy and asthma symptoms in the PIAMA birth cohort at the age of 4 yr. High-risk children (allergic mother) were prenatally recruited and randomly allocated to three groups; receiving mite allergen impermeable mattress covers (n = 416), placebo covers (n = 394) or no intervention (n = 472). At 4 yr of age, atopy was assessed by questionnaire; specific Immunoglobulin E (IgE) to inhalant and food allergens was measured in serum. Dust samples collected from the children's mattresses were analysed for mite allergens. Dermatophagoides farinae1 allergen (Der f 1) levels in dust were reduced in the active group. However, Dermatophagoides pteronissinus 1 (Der p 1) levels, sensitization and atopic symptoms were similar in all groups. We found no effect of mite allergen impermeable mattress covers on sensitization and atopy at 4 yr. Moreover, the allergen reducing effects of the covers had disappeared for one of the two mite allergens that were measured.

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