Placental p,p′-dichlorodiphenyldichloroethylene and cord blood immune markers

Authors

  • Kevin Brooks,

    1. Department of Epidemiology and Biostatistics, Norman J. Arnold School of Public Health, University of South Carolina, Columbia, SC
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  • Hanem Hasan,

    1. Food Allergy & Immunology Laboratory, Food Science & Human Nutrition; National Food Safety & Toxicology Center, Michigan State University, East Lansing, MI, USA
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  • Sridhar Samineni,

    1. Food Allergy & Immunology Laboratory, Food Science & Human Nutrition; National Food Safety & Toxicology Center, Michigan State University, East Lansing, MI, USA
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  • Venu Gangur,

    1. Food Allergy & Immunology Laboratory, Food Science & Human Nutrition; National Food Safety & Toxicology Center, Michigan State University, East Lansing, MI, USA
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  • Wilfried Karmaus

    1. Department of Epidemiology and Biostatistics, Norman J. Arnold School of Public Health, University of South Carolina, Columbia, SC
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Wilfried Karmaus, Department of Epidemiology and Biostatistics, Norman J. Arnold School of Public Health, University of South Carolina, 800 Sumter Street, Columbia, SC 29208-0001, USA
Tel.: 1-803-777-9814
Fax: 1-803-777-2524
E-mail: karmaus@sc.edu

Abstract

Placental p,p′-dichlorodiphenyldichloroethylene (p,p′-DDE) concentration and cord blood atopic markers were determined in 19 neonates. Increased placental p,p′-DDE was associated with a statistically significant increase in cord plasma interleukin (IL)-13. Furthermore, both cord plasma IL-4/interferon (IFN)-γ and IL-13/IFN-γ ratios were significantly positively associated with placental p,p′-DDE concentration.

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