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Environmental risk factors for early infantile atopic dermatitis

Authors

  • I. J. Wang,

    1. Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University College of Public Health, Taipei, Taiwan
    2. Department of Pediatrics, Taipei Hospital, Department of Health, Taipei County, Taiwan
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  • Y. L. Guo,

    1. Department of Environmental and Occupational Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
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  • H. J. Weng,

    1. Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan
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  • W. S. Hsieh,

    1. Department of Pediatrics, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
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  • Y. L. Chuang,

    1. Population and Health Research Center, Bureau of Health Promotion, Department of Health, Taichung, Taiwan
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  • S. J. Lin,

    1. Department of Pediatrics, National Cheng Kung University Hospital and College of Medicine, National Cheng Kung University, Tainan, Taiwan
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  • P. C. Chen

    1. Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University College of Public Health, Taipei, Taiwan
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Prof. Pau-Chung Chen, Institute of Occupational Medicine and Industrial Hygiene, College of Public Health, National Taiwan University, No. 17 Syujhou Road, Taipei 10055, Taiwan
Tel.: +886-2-33228088
Fax: +886-2-23582402
E-mail: prchen@ntu.edu.tw

Abstract

Previous studies of predictors of atopic dermatitis (AD) in Asia have had limited sample size and small numbers of variables focused primarily on family history or dietary exposures. The purpose of this study was to evaluate the influence of various environmental risk factors for early infantile AD. We used multistage, stratified systematic sampling to recruit 2048 mother–child pairs from the Taiwan national birth registration in 2003. Information on environmental risk factors for infant AD gathered by questionnaire were available from 1760 infants at 6 months of age. Multiple logistic regression was used to estimate adjusted odds ratios (aORs) and their 95% confidence intervals (CIs) for risk factors for AD after adjusting for potential confounders. AD was noted in 118 of 1760 (6.7%) of the infants. After adjusting for maternal age and education, family history of atopy, infant gender, and gestational age, fungi on walls of the house [aOR 2.14 (95% CI 1.41–3.22)] and frequent use of microwave oven at home [aOR 1.71 (95% CI 1.13–2.58)] increased the risk of early infantile AD. This study suggests that environmental factors do play a role in early infantile AD. Fungi, a kind of aeroallergen, are especially important in humid climate as in Taiwan and their impacts might be felt at the early infant stage. The hazards of microwave use should be paid more attention.

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