Ulrike Benninghoff and Federica Cattaneo have equally contributed to this work.
Clinical improvement and normalized Th1 cytokine profile in early and long-term interferon-α treatment in a suspected case of hyper-IgE syndrome
Article first published online: 18 AUG 2008
© 2007 The Authors. Journal compilation © 2007 Blackwell Munksgaard
Pediatric Allergy and Immunology
Volume 19, Issue 6, pages 564–568, September 2008
How to Cite
Benninghoff, U., Cattaneo, F., Aiuti, A., Flores-D’Arcais, A., Gelmetti, C., Viscardi, M., Callegaro, L., Mirolo, M., Ambrosi, A., Roncarolo, M. G. and Bacchetta, R. (2008), Clinical improvement and normalized Th1 cytokine profile in early and long-term interferon-α treatment in a suspected case of hyper-IgE syndrome. Pediatric Allergy and Immunology, 19: 564–568. doi: 10.1111/j.1399-3038.2007.00683.x
- Issue published online: 18 AUG 2008
- Article first published online: 18 AUG 2008
- Accepted 8 October 2007
- hyper-IgE syndrome;
We are reporting on a 7-months-old boy with suspected hyper-IgE syndrome, presenting with a therapy resistant severe eczema and an overall reduction of in vitro cytokine production. Interferon-α (IFN-α) treatment resulted in a marked and stable clinical improvement and normalization of in vitro T-cell cytokine production, indicating a valid therapeutic potential of IFN-α as immunomodulating drug.