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Clinical improvement and normalized Th1 cytokine profile in early and long-term interferon-α treatment in a suspected case of hyper-IgE syndrome


  • Ulrike Benninghoff and Federica Cattaneo have equally contributed to this work.

Rosa Bacchetta, San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET), Via Olgettina 58, I-20132 Milano, Italy
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We are reporting on a 7-months-old boy with suspected hyper-IgE syndrome, presenting with a therapy resistant severe eczema and an overall reduction of in vitro cytokine production. Interferon-α (IFN-α) treatment resulted in a marked and stable clinical improvement and normalization of in vitro T-cell cytokine production, indicating a valid therapeutic potential of IFN-α as immunomodulating drug.

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